Improved biocatalysts by directed evolution and rational protein design (Q28209721)

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7 January 2021

Directed evolution of biocatalysts

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7 January 2021

Directed Evolution of Enzymes

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7 January 2021

Designed evolution of enzymatic properties

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7 January 2021

Directed evolution: the 'rational' basis for 'irrational' design.

1 reference

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7 January 2021

Evolutionary optimisation of enzymes

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7 January 2021

Directed evolution of an esterase: screening of enzyme libraries based on pH-indicators and a growth assay

1 reference

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7 January 2021

Substrate phage: selection of protease substrates by monovalent phage display

1 reference

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7 January 2021

Processing and functional display of the 86 kDa heterodimeric penicillin G acylase on the surface of phage fd.

1 reference

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7 January 2021

A strategy for the isolation of catalytic activities from repertoires of enzymes displayed on phage 1 1Edited by J. Karn

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7 January 2021

A method for directed evolution and functional cloning of enzymes

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7 January 2021

Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold

1 reference

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7 January 2021

Directed evolution of an enantioselective lipase

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7 January 2021

Crystal structure of pseudomonas aeruginosa lipase in the open conformation. The prototype for family I.1 of bacterial lipases

1 reference

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7 January 2021

Directed evolution of an esterase from Pseudomonas fluorescens. Random mutagenesis by error-prone PCR or a mutator strain and identification of mutants showing enhanced enantioselectivity by a resorufin-based fluorescence assay.

1 reference

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7 January 2021

A Method for High-Throughput Screening of Enantioselective Catalysts

1 reference

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7 January 2021

Super-High-Throughput Screening of Enantioselective Catalysts by Using Capillary Array Electrophoresis

1 reference

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7 January 2021

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

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7 January 2021

Directed evolution of the fatty-acid hydroxylase P450 BM-3 into an indole-hydroxylating catalyst

1 reference

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7 January 2021

Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine

1 reference

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7 January 2021

Directed molecular evolution of cytochrome c peroxidase

1 reference

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7 January 2021

Exploring nonnatural evolutionary pathways by saturation mutagenesis: rapid improvement of protein function

1 reference

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7 January 2021

Directed evolution study of temperature adaptation in a psychrophilic enzyme

1 reference

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7 January 2021

DNA shuffling of subgenomic sequences of subtilisin

1 reference

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7 January 2021

Molecular breeding of carotenoid biosynthetic pathways

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7 January 2021

Tailoring new enzyme functions by rational redesign

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7 January 2021

Engineering enzyme specificity.

1 reference

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7 January 2021

Probing structural determinants specifying high thermostability in Bacillus licheniformis alpha-amylase

1 reference

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7 January 2021

Increasing the thermostability of D-xylose isomerase by introduction of a proline into the turn of a random coil

1 reference

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7 January 2021

Thermostabilization by Proline Substitution in an Alkaline, Liquefying α-Amylase from Bacillus sp. Strain KSM-1378

1 reference

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7 January 2021

Remarkable thermal stability of doubly intramolecularly cross-linked hen lysozyme

1 reference

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7 January 2021

Further improvement of the thermal stability of a partially stabilized Bacillus subtilis 3-isopropylmalate dehydrogenase variant by random and site-directed mutagenesis

1 reference

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7 January 2021

Bacterial formate dehydrogenase. Increasing the enzyme thermal stability by hydrophobization of alpha-helices

1 reference

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7 January 2021

Factors enhancing protein thermostability

1 reference

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7 January 2021

Stabilization of NAD-dependent formate dehydrogenase from Candida boidinii by site-directed mutagenesis of cysteine residues

1 reference

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7 January 2021

Phosphatidylcholine activation of human heart (R)-3-hydroxybutyrate dehydrogenase mutants lacking active center sulfhydryls: site-directed mutagenesis of a new recombinant fusion protein

1 reference

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7 January 2021

Inversion of stereospecificity of vanillyl-alcohol oxidase

1 reference

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7 January 2021

Rational design of Rhizopus oryzae lipase with modified stereoselectivity toward triradylglycerols

1 reference

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7 January 2021

Stereoselectivity of Mucorales lipases toward triradylglycerols--a simple solution to a complex problem

1 reference

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7 January 2021

Deletion of the four C-terminal residues of PepC converts an aminopeptidase into an oligopeptidase

1 reference

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7 January 2021

Protein engineering of cytochrome p450(cam) (CYP101) for the oxidation of polycyclic aromatic hydrocarbons

1 reference

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7 January 2021

Site-directed mutagenesis of residues 164, 170, 171, 179, 220, 237 and 242 in PER-1 beta-lactamase hydrolysing expanded-spectrum cephalosporins

1 reference

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7 January 2021

Optimization of the catalytic properties of Aspergillus fumigatus phytase based on the three-dimensional structure

1 reference

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7 January 2021

Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.

1 reference

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7 January 2021

Conversion of tyrosine phenol-lyase to dicarboxylic amino acid beta-lyase, an enzyme not found in nature

1 reference

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7 January 2021

Directed evolution of a fungal peroxidase

1 reference

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7 January 2021

A structural view of evolutionary divergence

1 reference

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7 January 2021

Redesigning the substrate specificity of an enzyme by cumulative effects of the mutations of non-active site residues

1 reference

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7 January 2021

Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.

1 reference

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7 January 2021

Enzyme engineering: rational redesign versus directed evolution

1 reference

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7 January 2021

Combinatorial and computational challenges for biocatalyst design

1 reference

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7 January 2021