Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes (Q28210085)

1

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Satomi Yogosawa

2

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Reiko Honda

3

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Tamotsu Nishida

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

20 December 2002

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published in

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volume

277

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issue

51

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page(s)

50131-6

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cites work

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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DNA damage induces phosphorylation of the amino terminus of p53

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

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p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

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A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

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Preferential modification of nuclear proteins by a novel ubiquitin-like molecule

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The ubiquitin-proteasome proteolytic pathway

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The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death

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In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2

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Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue

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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

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Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex

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Involvement of PIAS1 in the sumoylation of tumor suppressor p53

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An E3-like factor that promotes SUMO conjugation to the yeast septins

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Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates

21 January 2018

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SP-RING for SUMO: new functions bloom for a ubiquitin-like protein

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PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

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Inhibition of Stat1-mediated gene activation by PIAS1

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Specific inhibition of Stat3 signal transduction by PIAS3

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The nucleoporin RanBP2 has SUMO1 E3 ligase activity

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The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

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SUMO, ubiquitin's mysterious cousin

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RanBP2 associates with Ubc9p and a modified form of RanGAP1

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Covalent modification of PML by the sentrin family of ubiquitin-like proteins

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PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

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SUMO-1 modification activates the transcriptional response of p53

21 January 2018

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SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities

21 January 2018

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SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208319200

p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53.

21 January 2018

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SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

21 January 2018

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Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

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p19ARF links the tumour suppressor p53 to Ras

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M208319200

New structural clues to substrate specificity in the "ubiquitin system"

21 January 2018

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