The proteasome: a novel target for cancer chemotherapy (Q28215095)

The ubiquitin-proteasome proteolytic pathway

Europe PubMed Central

title

The proteasome: a novel target for cancer chemotherapy (English)

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J B Almond

1

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G M Cohen

series ordinal

2

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language of work or name

English

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publication date

April 2002

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published in

Leukemia

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volume

16

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issue

4

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page(s)

433-43

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cites work

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Self-compartmentalizing proteases.

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The proteasome: paradigm of a self-compartmentalizing protease

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Proteasome inhibitors as anti-cancer agents.

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Roles of ubiquitin-mediated proteolysis in cell cycle control

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How proteolysis drives the cell cycle

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The ubiquitin-proteasome pathway in cancer

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

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Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

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Caspases: the executioners of apoptosis

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Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

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Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

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Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

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Proteasome inhibitors: valuable new tools for cell biologists

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Proteasome inhibition: a new strategy in cancer treatment

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Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

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Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex

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The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis

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Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin

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Ubiquitin-proteasome system and increased sensitivity of B-CLL lymphocytes to apoptotic death activation

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Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome

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Proteasomes play an essential role in thymocyte apoptosis

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Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

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Prevention of etoposide-induced apoptosis by proteasome inhibitors in a human leukemic cell line but not in fresh acute leukemia blasts. A differential role of NF-kappab activation

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Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis

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p53 mutations in human cancers

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Apoptotic death sensor: an organelle's alter ego?

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Surfing the p53 network

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p53-dependent induction of apoptosis by proteasome inhibitors

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Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

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Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53

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7 January 2021

Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells

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7 January 2021

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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7 January 2021

p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

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Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

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Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

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Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

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ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein

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7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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7 January 2021

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

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7 January 2021

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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7 January 2021

The proteasome is involved in angiogenesis

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7 January 2021

Proteasome inhibitors as potential novel anticancer agents

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7 January 2021

Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit

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7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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7 January 2021

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

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7 January 2021

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

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7 January 2021

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

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7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

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7 January 2021

Eponemycin analogues: syntheses and use as probes of angiogenesis.

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7 January 2021

Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells

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7 January 2021

Apoptosis induction resulting from proteasome inhibition

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7 January 2021

Inhibition of Proteasome Function Prevents Thymocyte Apoptosis: Involvement of Ornithine Decarboxylase

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7 January 2021

Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration

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7 January 2021