Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo (Q28235379)

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28 January 2020

title

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo (English)

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28 January 2020

6

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Ingemar Björkhem

8

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28 January 2020

Ingemar Björkhem

9

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28 January 2020

author name string

M Shafaati

1

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28 January 2020

M Olin

2

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28 January 2020

A Båvner

3

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28 January 2020

H Pettersson

4

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28 January 2020

B Rozell

5

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28 January 2020

P Parini

7

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28 January 2020

language of work or name

English

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publication date

9 May 2011

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Journal of Internal Medicine

28 January 2020

published in

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28 January 2020

volume

270

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28 January 2020

page(s)

377-387

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issue

4

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The enzymes, regulation, and genetics of bile acid synthesis

28 January 2020

cites work

1 reference

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Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

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Are side-chain oxidized oxysterols regulators also in vivo?

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

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A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)

21 January 2018

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Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors

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LXR, a nuclear receptor that defines a distinct retinoid response pathway

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Liver X receptor modulators: a review of recently patented compounds (2007 - 2009).

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Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

21 January 2018

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Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

21 January 2018

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Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells.

21 January 2018

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Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene.

21 January 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

21 January 2018

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Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

21 January 2018

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Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis

21 January 2018

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From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

21 January 2018

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Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.

21 January 2018

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LXRS and FXR: the yin and yang of cholesterol and fat metabolism

21 January 2018

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Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.

21 January 2018

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Biliary sterol secretion is not required for macrophage reverse cholesterol transport

21 January 2018

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Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate

21 January 2018

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24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

21 January 2018

1 reference

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Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease

21 January 2018

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Biological activity of some oxygenated sterols

21 January 2018

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21 January 2018

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

2188729

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21486371%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

2188729

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

2188729