Chemical strategies for development of ATR inhibitors (Q28239738)

26 March 2017

5

Thomas Helleday

1 reference

26 March 2017

author name string

Sabin Llona-Minguez

1

1 reference

26 March 2017

Andreas Höglund

2

1 reference

26 March 2017

Sylvain A Jacques

3

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Tobias Koolmeister

4

1 reference

26 March 2017

Sylvain A. Jacques

3

1 reference

26 March 2017

language of work or name

English

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publication date

9 May 2014

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2014

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Expert Reviews in Molecular Medicine

26 March 2017

published in

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26 March 2017

volume

16

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

26 March 2017

page(s)

e10

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cites work

1 reference

ATR and ATRIP: partners in checkpoint signaling

21 April 2017

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DNA Damage, Aging, and Cancer

21 April 2017

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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

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Retraction: small molecule-based reversible reprogramming of cellular lifespan

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RETRACTED: Small molecule-based reversible reprogramming of cellular lifespan

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A role for ATR in the DNA damage-induced phosphorylation of p53

21 April 2017

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 April 2017

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 April 2017

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ATR signaling can drive cells into senescence in the absence of DNA breaks

21 April 2017

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https://api.crossref.org/works/10.1017%2FERM.2014.10

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

21 January 2018

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

21 January 2018

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The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

21 January 2018

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

21 January 2018

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Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

21 January 2018

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Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response

21 January 2018

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Repair of endogenous DNA damage

21 January 2018

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Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines

21 January 2018

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Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

21 January 2018

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RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

21 January 2018

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Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells

21 January 2018

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Prospects for the Use of ATR Inhibitors to Treat Cancer.

21 January 2018

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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

21 January 2018

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Anticancer therapy with checkpoint inhibitors: what, where and when?

21 January 2018

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New insights into checkpoint kinase 1 in the DNA damage response signaling network

21 January 2018

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Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance

21 January 2018

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Targeting the cancer kinome through polypharmacology

21 January 2018

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

21 January 2018

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The ATR barrier to replication-born DNA damage.

21 January 2018

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes

21 January 2018

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Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

21 January 2018

1 reference

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Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

21 January 2018

1 reference

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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.10

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

21 January 2018

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

21 January 2018

1 reference

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Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity

21 January 2018

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Correlation of DNA adduct levels in human lung with cigarette smoking

21 January 2018

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Targeting ATR in DNA damage response and cancer therapeutics.

21 January 2018

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7 January 2021

TopBP1 activates the ATR-ATRIP complex

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.10

7 January 2021

Selectively nonselective kinase inhibition: striking the right balance

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.10

7 January 2021

Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.10

7 January 2021

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.10

7 January 2021

CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors

1 reference

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7 January 2021

Identifiers

DOI

10.1017/ERM.2014.10

2 references

26 March 2017

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

24810715

1 reference

Consolidated OpenCitations Corpus – April 2017