Estrogen and progesterone receptors: from molecular structures to clinical targets (Q28239860)

Europe PubMed Central

title

Estrogen and progesterone receptors: from molecular structures to clinical targets (English)

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Stephan Ellmann

object named as

Stephan Ellmann

1

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Matthias W. Beckmann

4

object named as

Matthias W Beckmann

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author name string

Falk Thiel

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Reiner Strick

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Pamela L Strissel

Cellular and Molecular Life Sciences

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language of work or name

English

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publication date

August 2009

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published in

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volume

66

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issue

15

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page(s)

2405-26

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cites work

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Identification of membrane progestin receptors in human breast cancer cell lines and biopsies and their potential involvement in breast cancer

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12 December 2020

Breast cancer in men: should aromatase inhibitors become first-line hormonal treatment?

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12 December 2020

The transcriptional coactivators p300 and CBP are histone acetyltransferases

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12 December 2020

Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?

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12 December 2020

Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis

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12 December 2020

Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements

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12 December 2020

Direct interactions with G α i and G βγ mediate nongenomic signaling by estrogen receptor α .

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12 December 2020

Regression of uterine leiomyomata in response to the antiprogesterone RU 486.

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12 December 2020

The human estrogen receptor-alpha isoform hERalpha46 antagonizes the proliferative influence of hERalpha66 in MCF7 breast cancer cells

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12 December 2020

The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions

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12 December 2020

PTEN function in normal and neoplastic growth

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12 December 2020

Endometrial histopathology in 700 patients treated with tamoxifen for breast cancer

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12 December 2020

ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation

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12 December 2020

Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

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12 December 2020

A randomized, double-blind trial of a gonadotropin releasing-hormone agonist (leuprolide) with or without medroxyprogesterone acetate in the treatment of leiomyomata uteri

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12 December 2020

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I

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12 December 2020

The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT

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12 December 2020

The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes

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12 December 2020

Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer

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12 December 2020

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator

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12 December 2020

A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform

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12 December 2020

The effect of progestins on the mitotic activity of uterine fibromyomas

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12 December 2020

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

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12 December 2020

Loss of oestrogen receptor beta, high PCNA and p53 expression and aneuploidy as markers of worse prognosis in ovarian granulosa cell tumours

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12 December 2020

Mechanisms of estrogen action

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12 December 2020

A conserved mechanism for steroid receptor translocation to the plasma membrane

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12 December 2020

Nuclear receptor coregulators: cellular and molecular biology

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12 December 2020

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12 December 2020

Structure-based design of estrogen receptor-beta selective ligands

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12 December 2020

Role of endocytosis in cellular uptake of sex steroids.

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12 December 2020

Different expression of estrogen receptors alpha and beta in human myometrium and leiomyoma during the proliferative phase of the menstrual cycle and after GnRHa treatment

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12 December 2020

Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers.

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12 December 2020

Characterization of estrogen receptor-beta (ERbeta) messenger ribonucleic acid and protein expression in rat granulosa cells

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12 December 2020

Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol

1 reference

12 December 2020

Raloxifene, an oestrogen-receptor-beta-targeted therapy, inhibits androgen-independent prostate cancer growth: results from preclinical studies and a pilot phase II clinical trial.

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12 December 2020

The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization

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12 December 2020

Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube

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12 December 2020

Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors.

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12 December 2020

Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern

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12 December 2020

Preliminary report on the treatment of endometriosis with low-dose mifepristone (RU 486).

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12 December 2020

Atomic structure of progesterone complexed with its receptor

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12 December 2020

Nuclear receptor structure: implications for function

1 reference

12 December 2020

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

1 reference

12 December 2020

Two separate mechanisms for ligand-independent activation of the estrogen receptor.

1 reference

12 December 2020

Estrogen receptor interaction with estrogen response elements

1 reference

12 December 2020

Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements

1 reference

12 December 2020

Subunit composition of the molybdate-stabilized "8-9 S" nontransformed estradiol receptor purified from calf uterus

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12 December 2020

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

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12 December 2020

Mifepristone for luteal phase contraception

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12 December 2020

Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice.

1 reference

12 December 2020

Cloning of a novel receptor expressed in rat prostate and ovary

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12 December 2020

Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA binding

1 reference

12 December 2020

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

1 reference

12 December 2020

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1 reference

12 December 2020

Raloxifene in breast cancer prevention

1 reference

12 December 2020

Multiple effects of bioflavonoids on gene regulation, cell proliferation and apoptosis: natural compounds move into the lime light of cancer research

1 reference

12 December 2020

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors

1 reference

12 December 2020

Nature of functional estrogen receptors at the plasma membrane.

1 reference

12 December 2020

Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66.

1 reference

12 December 2020

Estrogen receptor corepressors -- a role in human breast cancer?

1 reference

12 December 2020

Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels

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12 December 2020

The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism.

1 reference

12 December 2020

Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium

1 reference

12 December 2020

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

1 reference

12 December 2020

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation

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12 December 2020

Molecular pathogenesis of granulosa cell tumours

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12 December 2020

The effect of raloxifene on the incidence of ovarian cancer in postmenopausal women

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12 December 2020

Low-grade endometrial stromal sarcoma: hormonal aspects

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12 December 2020

STRAP: editor for STRuctural Alignments of Proteins

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12 December 2020

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I

1 reference

12 December 2020

Effect of overexpression of progesterone receptor A on endogenous progestin-sensitive endpoints in breast cancer cells

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12 December 2020

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

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12 December 2020

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

1 reference

12 December 2020

The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens

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12 December 2020

Rapid screening of environmental chemicals for estrogen receptor binding capacity

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12 December 2020

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1 reference

12 December 2020

Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2

1 reference

12 December 2020

A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex

1 reference

12 December 2020

Estrogen receptors: how do they signal and what are their targets

1 reference

12 December 2020

Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase

1 reference

12 December 2020

Antiestrogenic properties of keoxifene, trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells.

1 reference

12 December 2020

Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor

1 reference

12 December 2020

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

1 reference

12 December 2020

Structural insights into corepressor recognition by antagonist-bound estrogen receptors

1 reference

12 December 2020

Hormones and hormone antagonists: mechanisms of action in carcinogenesis of endometrial and breast cancer

1 reference

12 December 2020

Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells

1 reference

12 December 2020

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

1 reference

12 December 2020

Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: consequence on DNA binding

1 reference

12 December 2020

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover

1 reference

12 December 2020

Loss of ERbeta expression as a common step in estrogen-dependent tumor progression

1 reference

12 December 2020

Chemoprevention of breast cancer with selective oestrogen-receptor modulators

1 reference

12 December 2020

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

1 reference

12 December 2020

Focus on endometrial and cervical cancer

1 reference

12 December 2020

Crystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonism

1 reference

12 December 2020

Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators

1 reference

12 December 2020

The SRC family of nuclear receptor coactivators

1 reference

12 December 2020

Molecular characterization of three forms of putative membrane-bound progestin receptors and their tissue-distribution in channel catfish, Ictalurus punctatus

1 reference

12 December 2020

MUC1 oncoprotein stabilizes and activates estrogen receptor alpha

1 reference

12 December 2020

Progesterone receptor transcription and non-transcription signaling mechanisms

1 reference

12 December 2020

8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein

1 reference

12 December 2020

Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta.

1 reference

12 December 2020

Transcriptional analysis of steroid hormone receptors in smooth muscle uterine leiomyoma tumors of postmenopausal patients.

1 reference

12 December 2020

The NR3B subgroup: an ovERRview

1 reference

12 December 2020

A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk

1 reference

12 December 2020

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions

1 reference

12 December 2020

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1 reference

12 December 2020

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities

1 reference

12 December 2020

Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity

1 reference

12 December 2020

Expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells

1 reference

12 December 2020

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling.

1 reference

12 December 2020

No association between the progesterone receptor gene +331G/A polymorphism and breast cancer.

1 reference

12 December 2020

Progesterone-binding components of chick oviduct. I. Preliminary characterization of cytoplasmic components

1 reference

12 December 2020

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

1 reference

12 December 2020

Genomic targets of nuclear estrogen receptors

1 reference

12 December 2020

Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains

1 reference

12 December 2020

Reproductive functions of progesterone receptors.

1 reference

12 December 2020

A transcriptional co-repressor that interacts with nuclear hormone receptors

1 reference

12 December 2020

Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours.

1 reference

12 December 2020

A structural biologist's view of the oestrogen receptor.

1 reference

12 December 2020

Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae

1 reference

12 December 2020

Effects of the progesterone antagonists onapristone (ZK 98 299) and ZK 136 799 on surgically induced endometriosis in intact rats

1 reference

12 December 2020

Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells

1 reference

12 December 2020

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1

1 reference

12 December 2020

Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells

1 reference

12 December 2020

Selective estrogen receptor modulators: an update on recent clinical findings

1 reference

12 December 2020

Sequence and expression of human estrogen receptor complementary DNA

1 reference

12 December 2020

Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases

1 reference

12 December 2020

Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia.

1 reference

12 December 2020

Early aberrant insulin-like growth factor signaling in the progression to endometrial carcinoma is augmented by tamoxifen

1 reference

12 December 2020

Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex

1 reference

12 December 2020

Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis

1 reference

12 December 2020

CBP-dependent and independent enhancing activity of steroid receptor coactivator-1 in thyroid hormone receptor-mediated transactivation

1 reference

12 December 2020

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors

1 reference

12 December 2020

The estradiol pharmacophore: ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site

1 reference

12 December 2020

Understanding the human estrogen receptor-alpha using targeted mutagenesis

1 reference

12 December 2020

Cancer statistics, 2008

1 reference

12 December 2020

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

1 reference

12 December 2020

The role of adapter protein Shc in estrogen non-genomic action

1 reference

12 December 2020

Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation

1 reference

12 December 2020

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer

1 reference

12 December 2020

Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs

1 reference

12 December 2020

Ligand-independent activation of pituitary ER: dependence on PKA-stimulated pathways

1 reference

12 December 2020

PGR +331 A/G and increased risk of epithelial ovarian cancer

1 reference

12 December 2020

Effects of selective estrogen receptor modulators (SERMs) on coactivator nuclear receptor (NR) box binding to estrogen receptors.

1 reference

12 December 2020

Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha

1 reference

12 December 2020

Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein

1 reference

12 December 2020

PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1

1 reference

12 December 2020

Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway.

1 reference

12 December 2020

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1 reference

12 December 2020

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B

1 reference

12 December 2020

The significance of estrogen receptor beta in 301 surgically treated non-small cell lung cancers

1 reference

12 December 2020

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women

1 reference

12 December 2020

Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization

1 reference

12 December 2020

Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes

1 reference

12 December 2020

Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen

1 reference

12 December 2020

Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities

1 reference

12 December 2020

Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels

1 reference

12 December 2020

Molecular determinants for the tissue specificity of SERMs

1 reference

12 December 2020

Effect of initial subcellular localization of progesterone receptor on import kinetics and transcriptional activity.

1 reference

12 December 2020

Localization of the human oestrogen receptor gene to chromosome 6q24----q27 by in situ hybridization

1 reference

12 December 2020

Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation

1 reference

12 December 2020

The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane

1 reference

12 December 2020

The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptors

1 reference

12 December 2020

The progesterone therapy of human uterine leiomyomas

1 reference

12 December 2020

Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term

1 reference

12 December 2020

Long-term medical therapy for leiomyomata uteri: a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin 'add-back' for 2 years

1 reference

12 December 2020

Molecular determinants of nuclear receptor-corepressor interaction

1 reference

12 December 2020

Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

1 reference

12 December 2020

Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis

1 reference

12 December 2020

Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform

1 reference

12 December 2020

Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis

1 reference

12 December 2020

Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor

1 reference

12 December 2020

A Galphas protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects of oestradiol on [Ca2+]i in female rat distal colon

1 reference

12 December 2020

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer

1 reference

12 December 2020

Effects of progesterone on growth factor expression in human uterine leiomyoma

1 reference

12 December 2020

Role of coactivators and corepressors in steroid and nuclear receptor signaling: potential markers of tumor growth and drug sensitivity

1 reference

12 December 2020

Two functionally relevant polymorphisms in the human progesterone receptor gene (+331 G/A and progins) and the predisposition for breast and/or ovarian cancer

1 reference

12 December 2020

Estrogen receptor pathways to AP-1.

1 reference

12 December 2020

No association between progesterone receptor gene +331G/A polymorphism and endometrial cancer

1 reference

12 December 2020

Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells

1 reference

12 December 2020

Development of peptide antagonists that target estrogen receptor-cofactor interactions

1 reference

12 December 2020

Cancer statistics, 2007

1 reference

12 December 2020

Helix 12 in the human estrogen receptor (hER) is essential for the hER function by overcoming nucleosome repression in yeast

1 reference

12 December 2020

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

1 reference

12 December 2020

Generation and reproductive phenotypes of mice lacking estrogen receptor beta

1 reference

12 December 2020

Estrogen receptor null mice: what have we learned and where will they lead us?

1 reference

12 December 2020

10.1007/S00018-009-0017-3

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

1905608

1905608

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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