Transient receptor potential channels as therapeutic targets (Q28244558)

Europe PubMed Central

title

Transient receptor potential channels as therapeutic targets (English)

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author name string

Magdalene M Moran

1

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Michael Allen McAlexander

2

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Tamás Bíró

3

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Arpad Szallasi

Nature Reviews Drug Discovery

4

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language of work or name

English

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publication date

1 August 2011

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published in

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volume

10

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issue

8

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page(s)

601-20

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cites work

Transient receptor potential channels: targeting pain at the source

1 reference

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

21 January 2018

1 reference

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

21 January 2018

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Transient receptor potential channelopathies

21 January 2018

1 reference

The vanilloid transient receptor potential channel TRPV4: from structure to disease

21 January 2018

1 reference

The capsaicin receptor: a heat-activated ion channel in the pain pathway

21 January 2018

1 reference

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

21 January 2018

1 reference

Attenuated fever response in mice lacking TRPV1

21 January 2018

1 reference

Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis.

21 January 2018

1 reference

The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.

21 January 2018

1 reference

Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade

21 January 2018

1 reference

Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial

21 January 2018

1 reference

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

21 January 2018

1 reference

Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats

21 January 2018

1 reference

The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans

21 January 2018

1 reference

Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival?

21 January 2018

1 reference

Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog

21 January 2018

1 reference

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

21 January 2018

1 reference

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

21 January 2018

1 reference

TRPA1 is a major oxidant sensor in murine airway sensory neurons

21 January 2018

1 reference

Desflurane induces airway contraction mainly by activating transient receptor potential A1 of sensory C-fibers

21 January 2018

1 reference

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

21 January 2018

1 reference

Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation

21 January 2018

1 reference

Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels

21 January 2018

1 reference

Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.

21 January 2018

1 reference

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

21 January 2018

1 reference

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

21 January 2018

1 reference

TRPA1 mediates formalin-induced pain

21 January 2018

1 reference

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

21 January 2018

1 reference

HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity

21 January 2018

1 reference

Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals

21 January 2018

1 reference

TRPA1 contributes to cold hypersensitivity

21 January 2018

1 reference

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation.

21 January 2018

1 reference

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

21 January 2018

1 reference

TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

21 January 2018

1 reference

Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors

21 January 2018

1 reference

A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome

21 January 2018

1 reference

TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation

21 January 2018

1 reference

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

21 January 2018

1 reference

Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain

21 January 2018

1 reference

Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

21 January 2018

1 reference

Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations

21 January 2018

1 reference

Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.

21 January 2018

1 reference

Noxious heat receptors present in cold-sensory cells in rats

21 January 2018

1 reference

TRPM8 is required for cold sensation in mice

21 January 2018

1 reference

The menthol receptor TRPM8 is the principal detector of environmental cold

21 January 2018

1 reference

Attenuated cold sensitivity in TRPM8 null mice

21 January 2018

1 reference

Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

21 January 2018

1 reference

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists

21 January 2018

1 reference

The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder

21 January 2018

1 reference

TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications.

21 January 2018

1 reference

Functional characterization of transient receptor potential channels in mouse urothelial cells

21 January 2018

1 reference

Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

21 January 2018

1 reference

Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals

21 January 2018

1 reference

Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms.

21 January 2018

1 reference

Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis

21 January 2018

1 reference

GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models

21 January 2018

1 reference

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

21 January 2018

1 reference

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

21 January 2018

1 reference

The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures

21 January 2018

1 reference

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Pa

21 January 2018

1 reference

Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations

21 January 2018

1 reference

AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome

21 January 2018

1 reference

Frontiers in pruritus research: scratching the brain for more effective itch therapy

21 January 2018

1 reference

TRP channels as novel players in the pathogenesis and therapy of itch

21 January 2018

1 reference

Vanilloid receptor-1 (VR1) is widely expressed on various epithelial and mesenchymal cell types of human skin

21 January 2018

1 reference

Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures.

21 January 2018

1 reference

Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin

21 January 2018

1 reference

TRPV1-mediated itch in seasonal allergic rhinitis.

21 January 2018

1 reference

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

21 January 2018

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Cutaneous wounds produced by capsaicin treatment of newborn rats are due to trophic disturbances.

21 January 2018

1 reference

VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.

21 January 2018

1 reference

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch

21 January 2018

1 reference

A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control

21 January 2018

1 reference

Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1.

21 January 2018

1 reference

Effects of skin surface temperature on epidermal permeability barrier homeostasis.

21 January 2018

1 reference

Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in vivo

21 January 2018

1 reference

A novel role for the TRPV1 channel in UV-induced matrix metalloproteinase (MMP)-1 expression in HaCaT cells

21 January 2018

1 reference

A heat-sensitive TRP channel expressed in keratinocytes

21 January 2018

1 reference

Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice.

21 January 2018

1 reference

Cough sensors. V. Pharmacological modulation of cough sensors.

21 January 2018

1 reference

Plasticity of peripheral mechanisms of cough.

21 January 2018

1 reference

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

21 January 2018

1 reference

TRPA1 agonists evoke coughing in guinea pig and human volunteers

21 January 2018

1 reference

Nicotine activates the chemosensory cation channel TRPA1.

21 January 2018

1 reference

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

21 January 2018

1 reference

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

21 January 2018

1 reference

Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange

21 January 2018

1 reference

A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension

21 January 2018

1 reference

Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes

21 January 2018

1 reference

Functional role of canonical transient receptor potential 1 and canonical transient receptor potential 3 in normal and asthmatic airway smooth muscle cells

21 January 2018

1 reference

Loss of classical transient receptor potential 6 channel reduces allergic airway response.

21 January 2018

1 reference

Functional TRPV4 channels are expressed in human airway smooth muscle cells

21 January 2018

1 reference

Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease

21 January 2018

1 reference

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.

21 January 2018

1 reference

High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4

21 January 2018

1 reference

TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.

21 January 2018

1 reference

Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2.

21 January 2018

1 reference

TRPV4 channels augment macrophage activation and ventilator-induced lung injury

21 January 2018

1 reference

Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss.

21 January 2018

1 reference

TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts

21 January 2018

1 reference

Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within the TRPV4 dysplasia family.

21 January 2018

1 reference

Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia

21 January 2018

1 reference

Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia

21 January 2018

1 reference

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

21 January 2018

1 reference

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

21 January 2018

1 reference

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.

21 January 2018

1 reference

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

21 January 2018

1 reference

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

21 January 2018

1 reference

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

21 January 2018

1 reference

Activation of NFAT signaling in podocytes causes glomerulosclerosis

21 January 2018

1 reference

Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6.

21 January 2018

1 reference

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family

21 January 2018

1 reference

Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia

21 January 2018

1 reference

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

21 January 2018

1 reference

New perspectives on enigmatic vanilloid receptors.

21 January 2018

1 reference

Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells

21 January 2018

1 reference

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.

21 January 2018

1 reference

Hot flash: TRPV channels in the brain.

21 January 2018

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Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens

21 January 2018

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TRPC channels promote cerebellar granule neuron survival.

21 January 2018

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TRPC3 channels are required for synaptic transmission and motor coordination

21 January 2018

1 reference

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

21 January 2018

1 reference

Essential role for TRPC5 in amygdala function and fear-related behavior.

21 January 2018

1 reference

TRPC5 is a regulator of hippocampal neurite length and growth cone morphology

21 January 2018

1 reference

TRP channels as mediators of oxidative stress

21 January 2018

1 reference

TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study.

21 January 2018

1 reference

A key role for TRPM7 channels in anoxic neuronal death

21 January 2018

1 reference

21 January 2018

Oncogenic TRP channels

1 reference

Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells

21 January 2018

1 reference

Central role of TRPM4 channels in cerebral blood flow regulation.

21 January 2018

1 reference

Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I

21 January 2018

1 reference

Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease.

21 January 2018

1 reference

Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice

21 January 2018

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TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy

21 January 2018

1 reference

TRPM5 regulates glucose-stimulated insulin secretion.

21 January 2018

1 reference

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

21 January 2018

1 reference

The emerging role of TRPV1 in diabetes and obesity

21 January 2018

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TRPV1-null mice are protected from diet-induced obesity

21 January 2018

1 reference

Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology

21 January 2018

1 reference

TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma.

21 January 2018

1 reference

Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease.

21 January 2018

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Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin

21 January 2018

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TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes.

21 January 2018

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Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis

21 January 2018

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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

21 January 2018

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Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells.

21 January 2018

1 reference

Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions

21 January 2018

1 reference

Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus)

21 January 2018

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TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness

21 January 2018

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Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans

21 January 2018

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Mutations in TRPM1 are a common cause of complete congenital stationary night blindness

21 January 2018

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Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice

21 January 2018

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N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker

21 January 2018

1 reference

Mice defective in Trpm6 show embryonic mortality and neural tube defects

21 January 2018

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Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis

21 January 2018

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A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders

21 January 2018

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Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase

21 January 2018

1 reference

Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study

21 January 2018

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Pkd1 and Pkd2 are required for normal placental development

21 January 2018

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TRP channels as cellular sensors

21 January 2018

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21 January 2018

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Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic mice.

21 January 2018

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Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats

31 March 2020

1 reference

Neurotoxin treatments for urinary incontinence in subjects with spinal cord injury or multiple sclerosis: a systematic review of effectiveness and adverse effects.

31 March 2020

1 reference

TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase

31 March 2020

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Association of a mutation in TRPV3 with defective hair growth in rodents

31 March 2020

1 reference

Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins

31 March 2020

1 reference

Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study

31 March 2020

1 reference

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

31 March 2020

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Induction of TRPC6 channel in acquired forms of proteinuric kidney disease

31 March 2020

1 reference

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

31 March 2020

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Hair cycle control by vanilloid receptor-1 (TRPV1): evidence from TRPV1 knockout mice

31 March 2020

1 reference

Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.

31 March 2020

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12 December 2020

Prostanoids and cough response to capsaicin in asthma and chronic bronchitis

1 reference

12 December 2020

NGX-4010, a high-concentration capsaicin dermal patch for lasting relief of peripheral neuropathic pain

1 reference

12 December 2020

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

1 reference

12 December 2020

Vanilloid (Capsaicin) receptors and mechanisms

1 reference

12 December 2020