STAT4: a critical regulator of inflammation in vivo (Q28250212)

Relative importance of STAT4 in murine tuberculosis

Europe PubMed Central

title

STAT4: a critical regulator of inflammation in vivo (English)

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Mark H Kaplan

1

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language of work or name

English

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publication date

2005

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published in

Immunologic Research

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volume

31

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page(s)

231-42

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issue

3

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cites work

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12 December 2020

Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection

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12 December 2020

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

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12 December 2020

Susceptibility to Leishmania mexicana infection is due to the inability to produce IL-12 rather than lack of IL-12 responsiveness.

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12 December 2020

Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii

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12 December 2020

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

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12 December 2020

Interleukin-12 and the regulation of innate resistance and adaptive immunity

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12 December 2020

Signal transducer and activator of transcription (Stat)-6-dependent, but not Stat4-dependent, immunity is required for the development of autoimmunity in Graves' hyperthyroidism

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12 December 2020

Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells

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12 December 2020

The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells

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12 December 2020

Attenuated cardiac allograft vasculopathy in mice with targeted deletion of the transcription factor STAT4

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12 December 2020

Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation

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12 December 2020

Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines

1 reference

12 December 2020

Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis

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12 December 2020

Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway.

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12 December 2020

Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells

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12 December 2020

Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.

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12 December 2020

Jaks and STATs: biological implications

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12 December 2020

IL-12, while beneficial, is not essential for the host response to VSV encephalitis

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12 December 2020

STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis

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12 December 2020

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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12 December 2020

Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses

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12 December 2020

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

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12 December 2020

T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

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12 December 2020

Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent

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12 December 2020

Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection

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12 December 2020

Infection-Triggered Regulatory Mechanisms Override the Role of STAT 4 in Control of the Immune Response to Influenza Virus Antigens

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12 December 2020

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

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12 December 2020

Autoimmune diabetes is blocked in Stat4-deficient mice

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12 December 2020

STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis

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12 December 2020

IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands

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12 December 2020

IL-4 and IL-12 Regulate Proteoglycan-Induced Arthritis Through Stat-Dependent Mechanisms

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12 December 2020

CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism

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12 December 2020

Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells

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12 December 2020

A STAT4-dependent Th1 response is required for resistance to the helminth parasite Taenia crassiceps.

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12 December 2020

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

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12 December 2020

Stat3 and Stat4: members of the family of signal transducers and activators of transcription

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12 December 2020

Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence

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12 December 2020

STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines.

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12 December 2020

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways

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12 December 2020

Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation

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12 December 2020

Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis

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12 December 2020

Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection

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12 December 2020

STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia

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12 December 2020

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

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12 December 2020

Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury

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12 December 2020

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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12 December 2020

Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice

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12 December 2020

A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

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12 December 2020

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo

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12 December 2020

Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4.

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12 December 2020

Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses

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12 December 2020

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

1 reference

12 December 2020

Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi

1 reference

12 December 2020

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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12 December 2020

CD4+ T cells regulate surgical and postinfectious adhesion formation

1 reference

12 December 2020

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.

1 reference

12 December 2020

Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets

1 reference

12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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12 December 2020

Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M

1 reference

12 December 2020

Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance

1 reference

12 December 2020

Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma

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12 December 2020

The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.

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12 December 2020

Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo.

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12 December 2020