Neonatal Fc receptor and IgG-based therapeutics (Q28252134)

X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn

published in

Monoclonal Antibodies

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volume

3

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issue

5

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page(s)

422-30

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cites work

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Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases

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The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland.

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The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release

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Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand.

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The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.

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Field flow fractionation for assessing neonatal Fc receptor and Fcγ receptor binding to monoclonal antibodies in solution.

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Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

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Transport of IgG across the blood-luminal barrier of the male reproductive tract of the rat and the effect of estradiol administration on reabsorption of fluid and IgG by the epididymal ducts.

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Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces

21 January 2018

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Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

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An engineered human IgG1 antibody with longer serum half-life.

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Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates

21 January 2018

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High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

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Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

21 January 2018

1 reference

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Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.16983

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

21 January 2018

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Prolonged activity of factor IX as a monomeric Fc fusion protein

21 January 2018

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Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent

21 January 2018

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The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin

21 January 2018

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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

21 January 2018

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Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis.

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Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

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Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

21 January 2018

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12 December 2020

Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice

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12 December 2020

Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences

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12 December 2020

Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade

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12 December 2020

The neonatal Fc receptor (FcRn) expression in the human skin

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12 December 2020

Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice

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12 December 2020

Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc

1 reference

12 December 2020

Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1

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12 December 2020

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

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12 December 2020

FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis

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12 December 2020

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

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12 December 2020

Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies

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12 December 2020

Identifiers

DOI

10.4161/MABS.3.5.16983

1 reference

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PubMed publication ID

22048693

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