DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer (Q28253026)

Journal of Molecular Histology

Europe PubMed Central

title

DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer (English)

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Ruth A Gjerset

1

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language of work or name

English

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publication date

September 2006

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published in

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volume

37

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issue

5-7

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page(s)

239-51

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cites work

Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1007%2FS10735-006-9040-Y

Partially processed pre-rRNA is preserved in association with processing components in nucleolus-derived foci during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10735-006-9040-Y

Regulation of p14ARF through subnuclear compartmentalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10735-006-9040-Y

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10735-006-9040-Y

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

12 December 2020

The ribonuclease activity of nucleolar protein B23.

1 reference

12 December 2020

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion

1 reference

12 December 2020

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

1 reference

12 December 2020

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

12 December 2020

E2F and cell cycle control: a double-edged sword

1 reference

12 December 2020

Monoclonal antibody to prostate cancer nuclear matrix protein (PRO:4-216) recognizes nucleophosmin/B23

1 reference

12 December 2020

Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

1 reference

12 December 2020

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

12 December 2020

Nucleophosmin is required for DNA integrity and p19Arf protein stability

1 reference

12 December 2020

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

1 reference

12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

12 December 2020

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

12 December 2020

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

1 reference

12 December 2020

Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.

1 reference

12 December 2020

Role of nucleophosmin in embryonic development and tumorigenesis

1 reference

12 December 2020

Nucleophosmin regulates the stability and transcriptional activity of p53

1 reference

12 December 2020

p14ARF links the tumour suppressors RB and p53.

1 reference

12 December 2020

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

12 December 2020

Sites of topoisomerase I action on X. laevis ribosomal chromatin: transcriptionally active rDNA has an approximately 200 bp repeating structure

1 reference

12 December 2020

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

1 reference

12 December 2020

A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.

1 reference

12 December 2020

Identification of a prominent nuclear protein associated with proliferation of normal and malignant B cells

1 reference

12 December 2020

Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

1 reference

12 December 2020

Interaction of nucleolar phosphoprotein B23 with nucleic acids

1 reference

12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

12 December 2020

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

12 December 2020

Enhanced tumor suppression by a p14ARF/p53 bicistronic adenovirus through increased p53 protein translation and stability.

1 reference

12 December 2020

Database of p53 gene somatic mutations in human tumors and cell lines

1 reference

12 December 2020

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

1 reference

12 December 2020

A novel p16INK4A transcript

1 reference

12 December 2020

Distinct roles for E2F proteins in cell growth control and apoptosis

1 reference

12 December 2020

Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification

1 reference

12 December 2020

An Arf(GFP/GFP) reporter mouse reveals that the Arf tumor suppressor monitors latent oncogenic signals in vivo

1 reference

12 December 2020

Tumor suppression and therapy sensitization of localized and metastatic breast cancer by adenovirus p53.

1 reference

12 December 2020

Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells

1 reference

12 December 2020

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

1 reference

12 December 2020

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

1 reference

12 December 2020

Restoring p53-dependent tumor suppression

1 reference

12 December 2020

Delineation of the domains required for physical and functional interaction of p14ARF with human topoisomerase I.

1 reference

12 December 2020

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

1 reference

12 December 2020

The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model

1 reference

12 December 2020

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

1 reference

12 December 2020

NPM mutations in acute myelogenous leukemia

1 reference

12 December 2020

Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers

1 reference

12 December 2020

The role of p53 in hypoxia-induced apoptosis

1 reference

12 December 2020

Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

1 reference

12 December 2020

Regulation of p53 stability by Mdm2

1 reference

12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

12 December 2020

Expression of nucleophosmin/B23 in normal and neoplastic colorectal mucosa.

1 reference

12 December 2020

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

12 December 2020

Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells

1 reference

12 December 2020

Targeting the p53-MDM2 interaction to treat cancer

1 reference

12 December 2020

The loss of mdm2 induces p53-mediated apoptosis

1 reference

12 December 2020

Sensitization of tumors to chemotherapy through gene therapy

1 reference

12 December 2020

p19ARF links the tumour suppressor p53 to Ras

1 reference

12 December 2020

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

12 December 2020

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

12 December 2020

The p53-mdm-2 autoregulatory feedback loop

1 reference

12 December 2020

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

12 December 2020

Mdm2 promotes the rapid degradation of p53

1 reference

12 December 2020

p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts

1 reference

12 December 2020

Abnormal centrosome amplification in the absence of p53.

1 reference

12 December 2020

Modification of nucleolar protein B23 after exposure to ionizing radiation

1 reference

12 December 2020

Human ARF protein interacts with topoisomerase I and stimulates its activity

1 reference

12 December 2020

Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53.

1 reference

12 December 2020

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

12 December 2020

Human p14(Arf): an exquisite sensor of morphological changes and of short-lived perturbations in cell cycle and in nucleolar function

1 reference

12 December 2020

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

1 reference

12 December 2020

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

1 reference

12 December 2020

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

12 December 2020

Identification of c-myc responsive genes using rat cDNA microarray.

1 reference

12 December 2020

Sensing cellular stress: another new function for the nucleolus?

1 reference

12 December 2020

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

12 December 2020

"Numatrin," a nuclear matrix protein associated with induction of proliferation in B lymphocytes

1 reference

12 December 2020

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

12 December 2020

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

12 December 2020

Expression of p14ARF overcomes tumor resistance to p53.

1 reference

12 December 2020

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

1 reference

12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

12 December 2020

Ultraviolet radiation triggers the ribotoxic stress response in mammalian cells.

1 reference

12 December 2020

Participation of p53 protein in the cellular response to DNA damage

1 reference

12 December 2020

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

1 reference

12 December 2020

Down-regulation of nucleophosmin/B23 during retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.

1 reference

12 December 2020

Gene therapy approaches to sensitization of human prostate carcinoma to cisplatin by adenoviral expression of p53 and by antisense jun kinase oligonucleotide methods

1 reference

12 December 2020

Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms

1 reference

12 December 2020

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

12 December 2020

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

1 reference

12 December 2020

Major nucleolar proteins shuttle between nucleus and cytoplasm

1 reference

12 December 2020

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

1 reference

12 December 2020

Nucleophosmin/B23-binding peptide inhibits tumor growth and up-regulates transcriptional activity of p53.

1 reference

12 December 2020

Adenoviral p53 gene therapy in squamous cell cancer of the head and neck region.

1 reference

12 December 2020

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

1 reference

12 December 2020

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

12 December 2020

Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.

1 reference

12 December 2020

Sensitization of rat glioblastoma multiforme to cisplatin in vivo following restoration of wild-type p53 function

1 reference

12 December 2020

Preribosomal ribonucleoprotein particles are a major component of a nucleolar matrix fraction

1 reference

12 December 2020

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

1 reference

12 December 2020

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization

1 reference

12 December 2020

Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expression

1 reference

12 December 2020

Mutations in theINK4a/ARFMelanoma Susceptibility Locus Functionally Impair p14ARF

1 reference

12 December 2020

The INK4a/ARF network in tumour suppression

1 reference

12 December 2020

Regulation and activation of p53 and its family members

1 reference

12 December 2020

Covalent and noncovalent modifiers of the p53 protein

1 reference

12 December 2020

Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus

1 reference

12 December 2020

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

12 December 2020

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

12 December 2020

Nucleophosmin sets a threshold for p53 response to UV radiation

1 reference

12 December 2020

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

1 reference

12 December 2020

DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.

1 reference

12 December 2020

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

1 reference

12 December 2020

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

1 reference

12 December 2020

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

12 December 2020

Surfing the p53 network

1 reference

12 December 2020

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

12 December 2020

Complex structure and regulation of the P16 (MTS1) locus

1 reference

12 December 2020

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

1 reference

12 December 2020

N-terminal polyubiquitination and degradation of the Arf tumor suppressor

1 reference

12 December 2020

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

12 December 2020

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1 reference

12 December 2020

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1 reference

12 December 2020

Characterization of nucleophosmin (B23) as a Myc target by scanning chromatin immunoprecipitation

1 reference

12 December 2020

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

1 reference

12 December 2020