Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers (Q28257103)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25686104%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers (English)

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1 March 2020

1

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1 March 2020

author name string

Katherine M Aird

2

1 reference

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1 March 2020

Azat Garipov

3

1 reference

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1 March 2020

Hua Li

4

1 reference

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1 March 2020

Michael Amatangelo

5

1 reference

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1 March 2020

Andrew V Kossenkov

6

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1 March 2020

David C Schultz

7

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1 March 2020

Qin Liu

8

1 reference

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1 March 2020

Ie-Ming Shih

9

1 reference

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1 March 2020

Jose R Conejo-Garcia

10

1 reference

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1 March 2020

David W Speicher

11

1 reference

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1 March 2020

Rugang Zhang

12

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1 March 2020

language of work or name

English

0 references

publication date

16 February 2015

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1 March 2020

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1 March 2020

volume

21

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1 March 2020

page(s)

231-238

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1 March 2020

issue

3

1 reference

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Discovery and saturation analysis of cancer genes across 21 tumour types

1 March 2020

cites work

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20 March 2017

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ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF

20 March 2017

1 reference

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Fast gapped-read alignment with Bowtie 2

20 March 2017

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ARID1A mutations in endometriosis-associated ovarian carcinomas

20 March 2017

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Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

20 March 2017

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PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma

20 March 2017

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PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein

20 March 2017

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Statistical significance for genomewide studies

20 March 2017

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Type-specific cell line models for type-specific ovarian cancer research

20 March 2017

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Identification of novel therapeutic targets in microdissected clear cell ovarian cancers

20 March 2017

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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

20 March 2017

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

7 April 2017

1 reference

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ARID1B is a specific vulnerability in ARID1A-mutant cancers.

7 April 2017

1 reference

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Promiscuous RNA binding by Polycomb repressive complex 2.

29 September 2017

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ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas

29 September 2017

1 reference

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

29 September 2017

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An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352133

Lessons from the cancer genome

29 September 2017

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352133

Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions

29 September 2017

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

29 September 2017

1 reference

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SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.

29 September 2017

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ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches

29 September 2017

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Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.

29 September 2017

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ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers

29 September 2017

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Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence

29 September 2017

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SWI/SNF nucleosome remodellers and cancer.

29 September 2017

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ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

29 September 2017

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Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells

29 September 2017

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29 September 2017

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29 September 2017

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A comprehensive evaluation of SAM, the SAM R-package and a simple modification to improve its performance

29 September 2017

1 reference

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The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

29 September 2017

1 reference

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Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila

29 September 2017

1 reference

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Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells

29 September 2017

1 reference

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The epigenetic magic of histone lysine methylation.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3799

Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3799

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25686104

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.3799

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25686104%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25686104%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25686104%20AND%20SRC:MED&resulttype=core&format=json