Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation (Q34317380)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23236167%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation (English)

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20 February 2020

1

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20 February 2020

author name string

HoMan Chan

2

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20 February 2020

Lin Teng

3

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20 February 2020

Ling Li

4

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20 February 2020

Shannon Chuai

5

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20 February 2020

Ruipeng Zhang

6

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20 February 2020

Jue Zeng

7

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20 February 2020

Min Li

8

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20 February 2020

Hong Fan

9

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20 February 2020

Ying Lin

10

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20 February 2020

Justin Gu

11

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20 February 2020

Ophelia Ardayfio

12

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20 February 2020

Ji-Hu Zhang

13

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20 February 2020

Xiaoxia Yan

14

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20 February 2020

Jialuo Fang

15

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20 February 2020

Yuan Mi

16

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20 February 2020

Man Zhang

17

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20 February 2020

Tao Zhou

18

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20 February 2020

Grace Feng

19

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20 February 2020

Zijun Chen

20

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20 February 2020

Guobin Li

21

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20 February 2020

Teddy Yang

22

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20 February 2020

Kehao Zhao

23

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20 February 2020

Xianghui Liu

24

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20 February 2020

Zhengtian Yu

25

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20 February 2020

Chris X Lu

26

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20 February 2020

Peter Atadja

27

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20 February 2020

En Li

28

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20 February 2020

language of work or name

English

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publication date

10 December 2012

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Proceedings of the National Academy of Sciences of the United States of America

20 February 2020

published in

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20 February 2020

volume

109

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20 February 2020

page(s)

21360-21365

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20 February 2020

issue

52

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

20 February 2020

cites work

1 reference

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

6 July 2018

1 reference

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Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis.

6 July 2018

1 reference

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

6 July 2018

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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535655

EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas

6 July 2018

1 reference

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Structural Chemistry of Human SET Domain Protein Methyltransferases

6 July 2018

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The Polycomb complex PRC2 and its mark in life

6 July 2018

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EZH2 Y641 mutations in follicular lymphoma.

6 July 2018

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

6 July 2018

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

6 July 2018

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Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

6 July 2018

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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

6 July 2018

1 reference

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Regulation of tumor angiogenesis by EZH2.

6 July 2018

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Polycomb group protein-mediated repression of transcription

6 July 2018

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

6 July 2018

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Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression

6 July 2018

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Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia

6 July 2018

1 reference

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Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

6 July 2018

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Cell cycle, CDKs and cancer: a changing paradigm

6 July 2018

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Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1

6 July 2018

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EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

6 July 2018

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

6 July 2018

1 reference

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The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing.

6 July 2018

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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

6 July 2018

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Polycomb silencers control cell fate, development and cancer

6 July 2018

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Control of developmental regulators by Polycomb in human embryonic stem cells

6 July 2018

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

6 July 2018

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A library of gene expression signatures to illuminate normal and pathological lymphoid biology

6 July 2018

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6 July 2018

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SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

6 July 2018

1 reference

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Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535655

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

6 July 2018

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

6 July 2018

1 reference

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535655

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535655

The polycomb-group gene Ezh2 is required for early mouse development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535655

The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535655

A gene complex controlling segmentation in Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535655

Application of a human tumor colony-forming assay to new drug screening

6 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23236167

12 December 2020

inferred from PubMed ID database lookup

Mutations of CD79A, CD79B and EZH2 genes in immunodeficiency-related non-Hodgkin lymphomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23236167

12 December 2020

inferred from PubMed ID database lookup

Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23236167

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1210371110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23236167%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

release_d5tb4mfda5dptfwpx4k6qix7hi

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d5tb4mfda5dptfwpx4k6qix7hi

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23236167%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23236167%20AND%20SRC:MED&resulttype=core&format=json