Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance? (Q28257929)

Europe PubMed Central

title

Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance? (English)

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Jorg Kotzka

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ORCID Public Data File 2021

author name string

Dirk Müller-Wieland

series ordinal

2

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language of work or name

English

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publication date

April 2004

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published in

Expert Opinion on Therapeutic Targets

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volume

8

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issue

2

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page(s)

141-9

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141-149

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cites work

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Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection

21 January 2018

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Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

21 January 2018

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Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

21 January 2018

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Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

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Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

21 January 2018

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

21 January 2018

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 January 2018

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Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

21 January 2018

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Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

21 January 2018

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PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

21 January 2018

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MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro

21 January 2018

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A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter

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DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1

21 January 2018

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A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of the promoter for 3-hydroxy-3-methylglutaryl coenzyme A reductase

21 January 2018

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Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes

21 January 2018

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SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein

21 January 2018

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CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription

21 January 2018

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Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation

21 January 2018

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Structure, function, and activator-induced conformations of the CRSP coactivator

21 January 2018

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Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation

21 January 2018

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Composite co-activator ARC mediates chromatin-directed transcriptional activation

21 January 2018

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Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein

21 January 2018

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Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

21 January 2018

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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Diseases of liporegulation: new perspective on obesity and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.2.141

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Leptin-replacement therapy for lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Sterol regulatory element-binding proteins and reactive oxygen species: potential role in highly-active antiretroviral therapy (HAART)-associated lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141

Estrogen Activates the High-Density Lipoprotein Receptor Gene via Binding to Estrogen Response Elements and Interaction with Sterol Regulatory Element Binding Protein-1A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.2.141