Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid (Q28260445)

Biophysical characterization of interactions involving importin-alpha during nuclear import

Europe PubMed Central

title

Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid (English)

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K J Soprano

1

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E Purev

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2

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S Vuocolo

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3

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D R Soprano

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4

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language of work or name

English

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publication date

28 August 2006

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published in

Oncogene

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volume

25

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issue

38

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page(s)

5315-25

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cites work

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The Rb2/p130 gene product is a nuclear protein whose phosphorylation is cycle regulated

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SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells

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p27Kip1 accumulation is associated with retinoic-induced neuroblastoma differentiation: evidence of a decreased proteasome-dependent degradation

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Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter.

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Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells.

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Effects of receptor class- and subtype-selective retinoids and an apoptosis-inducing retinoid on the adherent growth of the NIH:OVCAR-3 ovarian cancer cell line in culture

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Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse

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Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.

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Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation

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Role of the LXCXE binding site in Rb function

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A Unique Domain of pRb2/p130 Acts as an Inhibitor of Cdk2 Kinase Activity

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7 January 2021

The nuclear pore complex: a jack of all trades?

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7 January 2021

4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptors

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7 January 2021

Position-dependent transcriptional regulation of the murine dihydrofolate reductase promoter by the E2F transactivation domain

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7 January 2021

Direct proteasome inhibition by clasto-lactacystin beta-lactone permits the detection of ubiquitinated p21(waf1) in ML-1 cells

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7 January 2021

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

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7 January 2021

Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription

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Regulation of nuclear import by phosphorylation adjacent to nuclear localization signals.

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Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors

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Elucidation of molecular events mediating induction of apoptosis by synthetic retinoids using a CD437-resistant ovarian carcinoma cell line

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Comparison of the mechanism of induction of apoptosis in ovarian carcinoma cells by the conformationally restricted synthetic retinoids CD437 and 4‐HPR

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Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: activation of the p38 MAP kinase signal pathway

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7 January 2021

Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines

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7 January 2021

13-cis-retinoic acid in the treatment of oral leukoplakia

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7 January 2021

E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest

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7 January 2021

Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease

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7 January 2021

Nuclear targeting signal recognition: a key control point in nuclear transport?

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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7 January 2021

Cancer statistics, 2005

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Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis

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7 January 2021

Regulation of nuclear localization: a key to a door

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7 January 2021

Dynamic localization of the nuclear import receptor and its interactions with transport factors

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Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence

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Rb-independent induction of apoptosis by bovine papillomavirus type 1 E7 in response to tumor necrosis factor alpha

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pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation

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The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions.

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High-dose chemotherapy and autologous bone marrow or stem cell reconstitution for solid tumors.

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7 January 2021

Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation.

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7 January 2021

Control of pRB phosphorylation

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7 January 2021

E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

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7 January 2021

Ovarian cancer and high-risk women—implications for prevention, screening, and early detection

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7 January 2021

Induction of S-phase entry by E2F transcription factors depends on their nuclear localization

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7 January 2021

Regulation by tumour antigens defines a role for PP2A in signal transduction

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7 January 2021

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

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7 January 2021

A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene.

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7 January 2021

Retinoblastoma protein family in cell cycle and cancer: a review

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7 January 2021

Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells

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7 January 2021

Interaction of PP2A catalytic subunit with Rb2/p130 is required for all-trans retinoic acid suppression of ovarian carcinoma cell growth

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7 January 2021

E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter.

1 reference

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7 January 2021

Two domains within the adenovirus type 12 E1A unique spacer have disparate effects on the interaction of E1A with P105-Rb and the transformation of primary mouse cells

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7 January 2021

Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide

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7 January 2021

Inhibition of breast and ovarian carcinoma cell growth by 1,25-dihydroxyvitamin D3 combined with retinoic acid or dexamethasone

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7 January 2021

Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1.

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7 January 2021

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

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7 January 2021

N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma

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7 January 2021

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

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7 January 2021

Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation

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7 January 2021

Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation

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7 January 2021

Antiproliferative mechanism of retinoid derivatives in ovarian cancer cells

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7 January 2021

E2F activity is regulated by cell cycle-dependent changes in subcellular localization

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7 January 2021

Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cells

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7 January 2021

An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene

1 reference

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7 January 2021

Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1.

1 reference

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7 January 2021

Serine/threonine protein phosphatases

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7 January 2021

Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

1 reference

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7 January 2021

p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

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7 January 2021

All-trans-retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209679

7 January 2021

Effects of conformationally restricted synthetic retinoids on ovarian tumor cell growth.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209679

7 January 2021

Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid

1 reference

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7 January 2021

Reduction of both RAR and RXR levels is required to maximally alter sensitivity of CA-OV3 ovarian tumor cells to growth suppression by all-trans-retinoic acid

1 reference

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7 January 2021

Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2a regulates the activities of G(1) cyclin-dependent kinases

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7 January 2021

Paclitaxel: a pharmacoeconomic review of its use in the treatment of ovarian cancer

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7 January 2021

Nuclear localization conferred by the pocket domain of the retinoblastoma gene product.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209679

7 January 2021

Retinoids and ovarian cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209679

7 January 2021

Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression

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7 January 2021