Pim kinase inhibitors: a survey of the patent literature (Q28271318)

Expert Opinion on Therapeutic Patents

Europe PubMed Central

title

Pim kinase inhibitors: a survey of the patent literature (English)

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Tina Morwick

1

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language of work or name

English

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publication date

February 2010

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published in

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volume

20

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issue

2

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page(s)

193-212

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cites work

The human Pim-2 proto-oncogene and its testicular expression

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https://api.crossref.org/works/10.1517/13543770903496442

Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/13543770903496442

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/13543770903496442

Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode

21 April 2017

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Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

21 April 2017

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Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase

21 April 2017

1 reference

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4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors

21 April 2017

1 reference

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Ruthenium half-sandwich complexes bound to protein kinase Pim-1

21 April 2017

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https://api.crossref.org/works/10.1517/13543770903496442

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

21 April 2017

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https://api.crossref.org/works/10.1517%2F13543770903496442

Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442

Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

21 January 2018

1 reference

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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

21 January 2018

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Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer

21 January 2018

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

21 January 2018

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A molecular compendium of genes expressed in multiple myeloma

21 January 2018

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Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase

21 January 2018

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The survival kinases Akt and Pim as potential pharmacological targets

21 January 2018

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The serine/threonine kinase Pim-1

21 January 2018

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Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

21 January 2018

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In vivo analysis of Pim-1 deficiency

21 January 2018

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

21 January 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

21 January 2018

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Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

21 January 2018

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Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

21 January 2018

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The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines

21 January 2018

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Current development of mTOR inhibitors as anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

21 January 2018

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The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

The Pim kinases control rapamycin-resistant T cell survival and activation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

21 January 2018

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A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

21 January 2018

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Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases

21 January 2018

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N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

21 January 2018

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Chemical inhibitors of protein kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Kinase inhibitors and the case for CH...O hydrogen bonds in protein-ligand binding

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442

Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

The regulation of protein function by multisite phosphorylation--a 25 year update

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Kinase domain mutations in cancer: implications for small molecule drug design strategies.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Targeting cancer with small molecule kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Targeting innate immunity protein kinase signalling in inflammation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770903496442

Anti-inflammatory agents as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442

The selectivity of inhibitors of protein kinase CK2: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442

Joining the cell survival squad: an emerging role for protein kinase CK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442

Protein kinase CK2 and its role in cellular proliferation, development and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442

Exploiting the PI3K/AKT pathway for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442

Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903496442