Exploiting the PI3K/AKT pathway for cancer drug discovery (Q29615120)

Europe PubMed Central

title

Exploiting the PI3K/AKT pathway for cancer drug discovery (English)

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30 April 2017

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Hennessy BT

1

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Smith DL

2

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30 April 2017

Ram PT

3

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Lu Y

4

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30 April 2017

Mills GB

5

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language of work or name

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30 April 2017

publication date

December 2005

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Nature Reviews Drug Discovery

30 April 2017

published in

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volume

4

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issue

12

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page(s)

988-1004

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cites work

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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

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Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

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Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

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Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility

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Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

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Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

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Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells

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A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction

31 March 2020

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Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways

31 March 2020

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Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells

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Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages

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p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

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Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression

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Oncogenic kinase signalling

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Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

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Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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AKT plays a central role in tumorigenesis

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

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Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells

31 March 2020

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Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression.

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MDM2 in Breast Cancer

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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TOR, a central controller of cell growth

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

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Translational control of the antiapoptotic function of Ras.

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Akt regulates growth by directly phosphorylating Tsc2

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

31 March 2020

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Tuberous sclerosis genes regulate cellular 14-3-3 protein levels

31 March 2020

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

31 March 2020

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

31 March 2020

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

31 March 2020

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The Akt-mTOR tango and its relevance to cancer

31 March 2020

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Management of cellular energy by the AMP-activated protein kinase system

31 March 2020

1 reference

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

31 March 2020

1 reference

The LKB1 tumor suppressor negatively regulates mTOR signaling

31 March 2020

1 reference

Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

31 March 2020

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

31 March 2020

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

31 March 2020

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

31 March 2020

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Role of VHL gene mutation in human cancer

31 March 2020

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Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling

31 March 2020

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Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling

31 March 2020

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Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines

31 March 2020

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PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

31 March 2020

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Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

31 March 2020

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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

31 March 2020

1 reference

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

31 March 2020

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Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.

31 March 2020

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AKT/PKB signaling mechanisms in cancer and chemoresistance

31 March 2020

1 reference

Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.

31 March 2020

1 reference

Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain

31 March 2020

1 reference

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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The PIK3CA gene is mutated with high frequency in human breast cancers.

31 March 2020

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

31 March 2020

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High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

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Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

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PIK3CA is implicated as an oncogene in ovarian cancer.

31 March 2020

1 reference

Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma.

31 March 2020

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PIK3CA as an oncogene in cervical cancer

31 March 2020

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Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.

31 March 2020

1 reference

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

31 March 2020

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Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

31 March 2020

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

31 March 2020

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Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

31 March 2020

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

31 March 2020

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

31 March 2020

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PTEN: one gene, many syndromes

31 March 2020

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Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions

31 March 2020

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31 March 2020

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Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype

31 March 2020

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PTEN promoter is methylated in a proportion of invasive breast cancers

31 March 2020

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Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.

31 March 2020

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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

31 March 2020

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Somatic mutations of the protein kinase gene family in human lung cancer

31 March 2020

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Colorectal cancer: mutations in a signalling pathway

31 March 2020

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Mutational analysis of the tyrosine phosphatome in colorectal cancers

31 March 2020

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

31 March 2020

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

31 March 2020

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Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers

31 March 2020

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Mutations of the BRAF gene in human cancer

31 March 2020

1 reference

HER-2/neu amplification and overexpression in endometrial carcinoma.

31 March 2020

1 reference

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

31 March 2020

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Lung cancer: intragenic ERBB2 kinase mutations in tumours

31 March 2020

1 reference

Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone

31 March 2020

1 reference

Autocrine Signalling Through erbB Receptors Promotes Constitutive Activation of Protein Kinase B/Akt in Breast Cancer Cell Lines

31 March 2020

1 reference

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

31 March 2020

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

31 March 2020

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Somatic mutations of EGFR in colorectal cancers and glioblastomas

31 March 2020

1 reference

Expression of constitutively activated EGFRvIII in non-small cell lung cancer

31 March 2020

1 reference

Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin

31 March 2020

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Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

31 March 2020

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Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents.

31 March 2020

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Phosphoinositide 3-kinase signalling--which way to target?

31 March 2020

1 reference

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

31 March 2020

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

31 March 2020

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A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer

31 March 2020

1 reference

Activity of rapamycin (AY-22,989) against transplanted tumors

31 March 2020

1 reference

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

31 March 2020

1 reference

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

31 March 2020

1 reference

Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway

31 March 2020

1 reference

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

31 March 2020

1 reference

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

31 March 2020

1 reference

Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway

31 March 2020

1 reference

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

31 March 2020

1 reference

Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

31 March 2020

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Biomarkers to predict response to epidermal growth factor receptor inhibitors

31 March 2020

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 March 2020

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Molecular therapeutics: promise and challenges

31 March 2020

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Mammalian target of rapamycin

31 March 2020

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Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants

31 March 2020

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MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network

31 March 2020

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31 March 2020

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31 March 2020

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The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

31 March 2020

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Ultrasensitivity in the mitogen-activated protein kinase cascade

31 March 2020

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Formation of regulatory patterns during signal propagation in a Mammalian cellular network

31 March 2020

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Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

31 March 2020

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Causal protein-signaling networks derived from multiparameter single-cell data

31 March 2020

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

31 March 2020

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

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FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia

31 March 2020

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

31 March 2020

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Mutant PIK3CA promotes cell growth and invasion of human cancer cells

31 March 2020

1 reference

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

31 March 2020

1 reference

Mechanisms of resistance development against trastuzumab (Herceptin) in an in vivo breast cancer model.

31 March 2020

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31 March 2020

Putting the rap on Akt.

1 reference

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

31 March 2020

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Clinical role of positron emission tomography in oncology

31 March 2020

1 reference

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

31 March 2020

1 reference

The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer

31 March 2020

1 reference

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Pleura mesothelioma: combined modality treatments

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7 January 2021

based on heuristic

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

674768

1000136134

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674768

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16341064

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30 April 2017

Consolidated OpenCitations Corpus – April 2017