Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation (Q28275098)

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Yifeng Lu

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Isam Qahwash

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Xiang-You Hu

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Ansi Chang

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Riqiang Yan

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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language of work or name

English

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publication date

September 2004

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published in

Nature Medicine

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volume

10

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issue

9

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page(s)

959-65

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cites work

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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BACE2 functions as an alternative alpha-secretase in cells

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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Inhibitor of neurite outgrowth in humans

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Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

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Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

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Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13

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cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

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7 January 2021

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

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Maturation and pro-peptide cleavage of beta-secretase

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Convertases other than furin cleave beta-secretase to its mature form.

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7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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Alzheimer's disease: treatments in discovery and development

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Nogo and its paRTNers

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No Nogo: now where to go?

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NI-35/250/nogo-a: a neurite growth inhibitor restricting structural plasticity and regeneration of nerve fibers in the adult vertebrate CNS.

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Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions.

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Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact.

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Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions.

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7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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7 January 2021

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

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Reconstitution of gamma-secretase activity

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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7 January 2021

Differentiation and death of premyelinating oligodendrocytes in developing rodent brain

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7 January 2021