Artemisinin Action and Resistance in Plasmodium falciparum (Q28276294)

Europe PubMed Central

title

Artemisinin Action and Resistance in Plasmodium falciparum (English)

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main subject

infectious disease

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Plasmodium falciparum

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David A Fidock

5

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Stuart A Ralph

object named as

Stuart A Ralph

4

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author name string

Leann Tilley

1

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Judith Straimer

2

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Nina F Gnädig

Plasmodium falciparum: multifaceted resistance to artemisinins

3

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language of work or name

English

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publication date

September 2016

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published in

Trends in Parasitology

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volume

32

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page(s)

682-96

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issue

9

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cites work

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Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology

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Sequence and structural analysis of BTB domain proteins

20 March 2017

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Identification of an antimalarial synthetic trioxolane drug development candidate

20 March 2017

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

20 March 2017

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Artemisinins target the SERCA of Plasmodium falciparum

20 March 2017

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20 March 2017

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Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai-Myanmar border, 1999-2011: an observational study

20 March 2017

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Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

20 March 2017

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Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

20 March 2017

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A proteomic view of the Plasmodium falciparum life cycle

7 April 2017

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The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages

7 April 2017

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Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum

24 May 2017

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PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking

24 May 2017

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24 May 2017

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Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.

29 September 2017

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29 September 2017

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29 September 2017

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Structure- and function-based design of Plasmodium-selective proteasome inhibitors

29 September 2017

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Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

29 September 2017

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Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children

29 September 2017

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Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

29 September 2017

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Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays

29 September 2017

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Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment

29 September 2017

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Malaria medicines: a glass half full?

29 September 2017

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Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007-2012

29 September 2017

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Polymorphisms in the K13-propeller gene in artemisinin-susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara, Mali

29 September 2017

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A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance of Plasmodium falciparum Following Artemisinin Treatment

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes

29 September 2017

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Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

29 September 2017

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Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

29 September 2017

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Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome

29 September 2017

1 reference

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Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria

29 September 2017

1 reference

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Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study

29 September 2017

1 reference

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Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

29 September 2017

1 reference

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Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

29 September 2017

1 reference

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Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

29 September 2017

1 reference

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Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system

29 September 2017

1 reference

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Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug.

29 September 2017

1 reference

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Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors.

29 September 2017

1 reference

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Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

29 September 2017

1 reference

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Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

29 September 2017

1 reference

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Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

29 September 2017

1 reference

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Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stage Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

29 September 2017

2 references

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29 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010.

27 November 2018

1 reference

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Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Insights into the role of heme in the mechanism of action of antimalarials

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

29 September 2017

1 reference

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The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

29 September 2017

1 reference

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First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

29 September 2017

1 reference

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Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

A major genome region underlying artemisinin resistance in malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts

29 September 2017

1 reference

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Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum

29 September 2017

1 reference

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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Falcipains and other cysteine proteases of malaria parasites

29 September 2017

1 reference

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Drug-resistant malaria: molecular mechanisms and implications for public health

29 September 2017

1 reference

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border

29 September 2017

1 reference

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Heme as trigger and target for trioxane-containing antimalarial drugs.

29 September 2017

1 reference

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The molecular mechanism of action of artemisinin--the debate continues.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Biological actions of artemisinin: insights from medicinal chemistry studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

In silico and biological survey of transcription-associated proteins implicated in the transcriptional machinery during the erythrocytic development of Plasmodium falciparum.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Born to bind: the BTB protein-protein interaction domain.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinins: mechanisms of action and potential for resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

A medicinal chemistry perspective on artemisinin and related endoperoxides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin: mechanisms of action, resistance and toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their anti-malarial activities are additive with toxic sphingolipid analogues that block the network

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artefenomel: a promising new antimalarial drug

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Bioinformatics analyses provide insight into distant homology of the Keap1-Nrf2 pathway.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Dihydroartemisinin-piperaquine failure in Cambodia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Artemisinin resistance in Plasmodium falciparum

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Pharmacokinetics and pharmacodynamics of arterolane maleate following multiple oral doses in adult patients with P. falciparum malaria.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Malaria's drug miracle in danger.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007624

de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27289273

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Morphologic effects of artemisinin in Plasmodium falciparum

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27289273