Mechanistic studies of the Nrf2-Keap1 signaling pathway (Q28277182)

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

Europe PubMed Central

title

Mechanistic studies of the Nrf2-Keap1 signaling pathway (English)

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author name string

Donna D Zhang

series ordinal

1

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language of work or name

English

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publication date

2006

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published in

Drug Metabolism Reviews

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volume

38

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page(s)

769-89

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issue

4

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cites work

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Ubiquitin-dependent protein degradation

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Crystal structure of the Kelch domain of human Keap1

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Mechanisms underlying ubiquitination

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 April 2017

1 reference

https://api.crossref.org/works/10.1080/03602530600971974

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600971974

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600971974

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600971974

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600971974

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 April 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600971974

Nuclear import and export signals in control of Nrf2.

21 April 2017

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.1074/JBC.M502083200