Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 (Q28583647)

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English	Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1	scientific journal article

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scholarly article

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PubMed publication ID

31 January 2017

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 (English)

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PubMed publication ID

31 January 2017

author name string

Truyen Nguyen

1

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PubMed publication ID

31 January 2017

Philip J. Sherratt

2

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PubMed publication ID

31 January 2017

Paul Nioi

3

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PubMed publication ID

31 January 2017

Chung S. Yang

4

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PubMed publication ID

31 January 2017

Cecil B. Pickett

5

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PubMed publication ID

31 January 2017

language of work or name

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publication date

16 September 2005

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PubMed publication ID

31 January 2017

Journal of Biological Chemistry

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PubMed publication ID

31 January 2017

280

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PubMed publication ID

31 January 2017

37

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PubMed publication ID

31 January 2017

32485–32492

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PubMed publication ID

31 January 2017

Nrf2 is essential for protection against acute pulmonary injury in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

c-Myc target gene specificity is determined by a post-DNAbinding mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Coexamination of site-specific transcription factor binding and promoter activity in living cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

CRM1 is an export receptor for leucine-rich nuclear export signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Evidence for a role of CRM1 in signal-mediated nuclear protein export

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Exportin 1 (Crm1p) is an essential nuclear export factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M503074200

21 January 2018

Identifiers

10.1074/JBC.M503074200

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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