LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain (Q28280001)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20400510%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain (English)

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31 January 2020

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1 reference

2

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31 January 2020

Masahiro Aoki

5

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31 January 2020

author name string

Atsuko Deguchi

1

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31 January 2020

Yasushi Kojima

3

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31 January 2020

Katsuya Okawa

4

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31 January 2020

Makoto M Taketo

6

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31 January 2020

language of work or name

English

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publication date

16 April 2010

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Journal of Biological Chemistry

31 January 2020

published in

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31 January 2020

volume

285

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31 January 2020

issue

24

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31 January 2020

page(s)

18283-18290

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The LKB1 tumor suppressor kinase in human disease

31 January 2020

cites work

1 reference

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p21-activated kinases in cancer

20 March 2017

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LKB1 tumor suppressor protein: PARtaker in cell polarity

20 March 2017

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

20 March 2017

1 reference

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p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

20 March 2017

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

20 March 2017

1 reference

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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

20 March 2017

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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

20 March 2017

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

20 March 2017

1 reference

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The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

20 March 2017

1 reference

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

20 March 2017

1 reference

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

20 March 2017

1 reference

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

20 March 2017

1 reference

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Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis

20 March 2017

1 reference

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Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

20 March 2017

1 reference

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cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets

20 March 2017

1 reference

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

20 March 2017

1 reference

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Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

20 March 2017

1 reference

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Biology of the p21-activated kinases

20 March 2017

1 reference

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LKB1 modulates lung cancer differentiation and metastasis

7 April 2017

1 reference

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The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity

24 May 2017

1 reference

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P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation.

29 September 2017

1 reference

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Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

29 September 2017

1 reference

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AMP-activated protein kinase regulates the assembly of epithelial tight junctions

29 September 2017

1 reference

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LKB1-dependent signaling pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881753

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881753

Mutations in the human LKB1/STK11 gene

29 September 2017

1 reference

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Pak-1 expression increases with progression of colorectal carcinomas to metastasis

29 September 2017

1 reference

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Emerging functions of p21-activated kinases in human cancer cells

29 September 2017

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

29 September 2017

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Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

29 September 2017

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Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice

29 September 2017

1 reference

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Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice

29 September 2017

1 reference

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The Akt proto-oncogene links Ras to Pak and cell survival signals

29 September 2017

1 reference

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Optimization of the helper-dependent adenovirus system for production and potency in vivo

29 September 2017

1 reference

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Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881753

Increased risk of cancer in the Peutz-Jeghers syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881753

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881753

Early cell motility changes associated with an increase in metastatic ability in rat prostatic cancer cells transfected with the v-Harvey-ras oncogene.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881753

Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.079137

PAK1 hyperactivation is sufficient for mammary gland tumor formation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.079137

Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.079137

Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881753

Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20400510

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.079137

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20400510%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20400510%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

20400510

1 reference