Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma (Q28284012)

Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

Europe PubMed Central

title

Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma (English)

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main subject

hepatocellular carcinoma

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Alla Arzumanyan

1

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Helena M G P V Reis

series ordinal

2

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Mark A Feitelson

series ordinal

3

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language of work or name

English

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publication date

February 2013

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published in

Nature Reviews Cancer

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volume

13

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issue

2

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page(s)

123-35

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cites work

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Control of cccDNA function in hepatitis B virus infection.

31 March 2020

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Expression of hepatitis B virus X protein is closely correlated with the high periportal inflammatory activity of liver diseases

31 March 2020

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Occult hepatitis B virus and hepatitis C virus infections

31 March 2020

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Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein.

31 March 2020

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Viral interaction and clinical implications of coinfection of hepatitis C virus with other hepatitis viruses

31 March 2020

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Frequent detection of hepatitis B virus DNA in hepatocellular carcinoma of patients with sustained virologic response for hepatitis C virus

31 March 2020

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection

31 March 2020

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Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.

31 March 2020

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Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

31 March 2020

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

31 March 2020

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Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients

31 March 2020

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Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B.

31 March 2020

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Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis

31 March 2020

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Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection

31 March 2020

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Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

31 March 2020

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Mechanism of the interferon alpha response against hepatitis C virus replicons

31 March 2020

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Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

31 March 2020

1 reference

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response

31 March 2020

1 reference

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

31 March 2020

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The presence of an intrahepatic cytotoxic T lymphocyte response is associated with low viral load in patients with chronic hepatitis C virus infection

31 March 2020

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Determinants of viral clearance and persistence during acute hepatitis C virus infection

31 March 2020

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Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC.

31 March 2020

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Hepatitis B virus X gene and hepatocarcinogenesis.

31 March 2020

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The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin

31 March 2020

1 reference

HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt.

31 March 2020

1 reference

The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways

31 March 2020

1 reference

The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage

31 March 2020

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Subcellular forms and biochemical events triggered in human cells by HCV polyprotein expression from a viral vector

31 March 2020

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Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential

31 March 2020

1 reference

Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response

31 March 2020

1 reference

Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4.

31 March 2020

1 reference

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver

31 March 2020

1 reference

The hepatitis B virus X protein elevates cytosolic calcium signals by modulating mitochondrial calcium uptake

31 March 2020

1 reference

Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication

31 March 2020

1 reference

Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species

31 March 2020

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Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic Adaptation

31 March 2020

1 reference

Targeting mitochondria in the infection strategy of the hepatitis C virus

31 March 2020

1 reference

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response

31 March 2020

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Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment

31 March 2020

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Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

31 March 2020

1 reference

The autophagy machinery is required to initiate hepatitis C virus replication

31 March 2020

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Autophagy is activated for cell survival after endoplasmic reticulum stress

31 March 2020

1 reference

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

31 March 2020

1 reference

Angiogenic activity of hepatitis B and C viruses.

31 March 2020

1 reference

Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1alpha

31 March 2020

1 reference

Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway

31 March 2020

1 reference

Hypoxia-inducible factors, stem cells, and cancer

31 March 2020

1 reference

Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein

31 March 2020

1 reference

Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor-κB/hypoxia-inducible factor-1α axis under hypoxic conditions

31 March 2020

1 reference

Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

31 March 2020

1 reference

Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancer

31 March 2020

1 reference

Tumour biology: senescence in premalignant tumours

31 March 2020

1 reference

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade

31 March 2020

1 reference

Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells

31 March 2020

1 reference

Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies

31 March 2020

1 reference

Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential

31 March 2020

1 reference

Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes

31 March 2020

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Ageing, telomeres, senescence, and liver injury.

31 March 2020

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

31 March 2020

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Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.

31 March 2020

1 reference

DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes

31 March 2020

1 reference

Epigenetic Drivers of Genetic Alterations

31 March 2020

1 reference

Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein

31 March 2020

1 reference

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

31 March 2020

1 reference

Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma

31 March 2020

1 reference

Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes

31 March 2020

1 reference

Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation

31 March 2020

1 reference

Hepatitis C virus Core protein overcomes stress-induced premature senescence by down-regulating p16 expression via DNA methylation

31 March 2020

1 reference

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

31 March 2020

1 reference

Tumour suppression by p53: a role for the DNA damage response?

31 March 2020

1 reference

Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma

31 March 2020

1 reference

Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122

31 March 2020

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Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma

31 March 2020

1 reference

Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition

31 March 2020

1 reference

Liver extracellular matrix in health and disease

31 March 2020

1 reference

Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options

31 March 2020

1 reference

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

31 March 2020

1 reference

EMT: when epithelial cells decide to become mesenchymal-like cells

31 March 2020

1 reference

Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy

31 March 2020

1 reference

The Snail genes as inducers of cell movement and survival: implications in development and cancer.

31 March 2020

1 reference

Epithelial-mesenchymal transition in hepatocellular carcinoma.

31 March 2020

1 reference

The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

31 March 2020

1 reference

TGF-beta-induced epithelial to mesenchymal transition

31 March 2020

1 reference

Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition

31 March 2020

1 reference

Epigenetic reprogramming and post-transcriptional regulation during the epithelial-mesenchymal transition

31 March 2020

1 reference

Hepatitis B virus X protein activates a survival signaling by linking SRC to phosphatidylinositol 3-kinase

31 March 2020

1 reference

c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication

31 March 2020

1 reference

HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line

31 March 2020

1 reference

The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner.

31 March 2020

1 reference

Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer.

31 March 2020

1 reference

Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors

31 March 2020

1 reference

Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein

31 March 2020

1 reference

HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1.

31 March 2020

1 reference

Hepatitis C virus E2 protein induce reactive oxygen species (ROS)-related fibrogenesis in the HSC-T6 hepatic stellate cell line

31 March 2020

1 reference

Novel therapeutic strategies for targeting liver cancer stem cells

31 March 2020

1 reference

Biology of hepatic cancer stem cells.

31 March 2020

1 reference

Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?

31 March 2020

1 reference

New hope for cancer treatment: exploring the distinction between normal adult stem cells and cancer stem cells

31 March 2020

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Human embryonic genes re-expressed in cancer cells

31 March 2020

1 reference

Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma

31 March 2020

1 reference

Embryonic stem cell markers expression in cancers.

31 March 2020

1 reference

Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts

31 March 2020

1 reference

WNT signaling pathway and stem cell signaling network

31 March 2020

1 reference

Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells

31 March 2020

1 reference

EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features

31 March 2020

1 reference

Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells

31 March 2020

1 reference

Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

31 March 2020

1 reference

Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells

31 March 2020

1 reference

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

31 March 2020

1 reference

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms

31 March 2020

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The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

1 reference

Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells

31 March 2020

1 reference

EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma

31 March 2020

1 reference

Proteomic analysis of HBV-associated HCC: insights on mechanisms of disease onset and biomarker discovery

31 March 2020

1 reference

Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis

31 March 2020

1 reference

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.

31 March 2020

1 reference

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

31 March 2020

1 reference

Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis.

31 March 2020

1 reference

Utility of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma

31 March 2020

1 reference

Hepatocellualar carcinoma serum markers

31 March 2020

1 reference

Identification of the antigens predominantly reacted with serum from patients with hepatocellular carcinoma

31 March 2020

1 reference

cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis

31 March 2020

1 reference

Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index

31 March 2020

1 reference

Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma

31 March 2020

1 reference

Microarray-based gene expression analysis of hepatocellular carcinoma

31 March 2020

1 reference

Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): an emerging field for advanced technologies.

31 March 2020

1 reference

A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma

31 March 2020

1 reference

Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis

31 March 2020

1 reference

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

31 March 2020

1 reference

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

31 March 2020

1 reference

No association of EGF 5'UTR variant A61G and hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection

31 March 2020

1 reference

Expression and gene polymorphisms of interleukin 28B and hepatitis B virus infection in a Chinese Han population

31 March 2020

1 reference

IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection

31 March 2020

1 reference

-509C>T polymorphism in the TGF-beta1 gene promoter, impact on the hepatocellular carcinoma risk in Chinese patients with chronic hepatitis B virus infection

31 March 2020

1 reference

The genotypes of IL-1 beta and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma

31 March 2020

1 reference

Molecular targeted therapies in hepatocellular carcinoma

31 March 2020

1 reference

Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product.

31 March 2020

1 reference

Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry

31 March 2020

1 reference

Focal overexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes in viral liver cirrhosis

31 March 2020

1 reference

Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells

31 March 2020

1 reference

Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells.

31 March 2020

1 reference

Targeted therapies for hepatocellular carcinoma.

31 March 2020

1 reference

Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma

31 March 2020

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Parallel epigenetic and genetic changes in the pathogenesis of hepatitis virus-associated hepatocellular carcinoma

31 March 2020

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

31 March 2020

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Emerging epigenetic targets and therapies in cancer medicine

31 March 2020

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31 March 2020

The hepatitis B virus

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Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

31 March 2020

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miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma

31 March 2020

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12 December 2020

Hepatitis B virus infection

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12 December 2020

Expression profile reveals novel prognostic biomarkers in hepatocellular carcinoma.

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12 December 2020

Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway

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12 December 2020

Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death

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12 December 2020

Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma.

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12 December 2020

[Regulation of microRNA-122 on HBV replication by targeting HBx sequence]

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12 December 2020

Hypoxia and hypoxia inducible factors in cancer stem cell maintenance

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12 December 2020

Hepatitis C virus population dynamics during infection.

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12 December 2020

Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins

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12 December 2020

TGF-beta1 and C-erb-B2 neu oncoprotein in Egyptian HCV related chronic liver disease and hepatocellular carcinoma patients

1 reference

12 December 2020