Tumour suppression by p53: a role for the DNA damage response? (Q37591937)

21 August 2017

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title

Tumour suppression by p53: a role for the DNA damage response? (English)

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21 August 2017

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David W Meek

1

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21 August 2017

language of work or name

English

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publication date

4 September 2009

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21 August 2017

published in

Nature Reviews Cancer

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21 August 2017

volume

9

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21 August 2017

issue

10

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21 August 2017

page(s)

714-723

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https://scigraph.springernature.com/pub.10.1038/nrc2716

21 August 2017

exact match

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cites work

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ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

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The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain

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Intrinsic tumour suppression

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

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Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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The INK4a/ARF network in tumour suppression

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

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p53 deficiency does not affect the accumulation of point mutations in a transgene target

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Restoration of p53 function leads to tumour regression in vivo

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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Cellular senescence: when bad things happen to good cells

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Cancer: crime and punishment.

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Eating to exit: autophagy-enabled senescence revealed.

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Autophagy mediates the mitotic senescence transition

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Dissecting p53 tumor suppressor functions in vivo

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Apoptosis: controlled demolition at the cellular level

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Mechanisms of regulatory diversity within the p53 transcriptional network

31 March 2020

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A complex barcode underlies the heterogeneous response of p53 to stress

31 March 2020

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

31 March 2020

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

31 March 2020

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

31 March 2020

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Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

31 March 2020

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Transcriptional control of human p53-regulated genes

31 March 2020

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A global map of p53 transcription-factor binding sites in the human genome

31 March 2020

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

31 March 2020

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p53 regulates maternal reproduction through LIF

31 March 2020

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

31 March 2020

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p53 regulates mitochondrial respiration

31 March 2020

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Control of cell migration: a tumour suppressor function for p53?

31 March 2020

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Regulation of AIF expression by p53.

31 March 2020

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Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome.

31 March 2020

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p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

31 March 2020

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

31 March 2020

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Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

31 March 2020

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

31 March 2020

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Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

31 March 2020

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

31 March 2020

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31 March 2020

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Tumor suppression by Ink4a-Arf: progress and puzzles

31 March 2020

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

31 March 2020

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

31 March 2020

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

31 March 2020

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Nucleolar Arf sequesters Mdm2 and activates p53

31 March 2020

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

31 March 2020

1 reference

ATM activity contributes to the tumor-suppressing functions of p14ARF.

31 March 2020

1 reference

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

31 March 2020

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DNA damage induces phosphorylation of the amino terminus of p53

31 March 2020

1 reference

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

31 March 2020

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

31 March 2020

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The INK4a/ARF locus in murine tumorigenesis

31 March 2020

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Involvement of the INK4a/Arf gene locus in senescence

31 March 2020

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

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Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts

31 March 2020

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

31 March 2020

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

1 reference

Living on a break: cellular senescence as a DNA-damage response

31 March 2020

1 reference

An oncogene-induced DNA damage model for cancer development

31 March 2020

1 reference

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

31 March 2020

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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

31 March 2020

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The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression

31 March 2020

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Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

31 March 2020

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Phosphorylation of serine 18 regulates distinct p53 functions in mice

31 March 2020

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Mutation of mouse p53 Ser23 and the response to DNA damage

31 March 2020

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Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

31 March 2020

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Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas

31 March 2020

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

31 March 2020

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The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts.

31 March 2020

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

31 March 2020

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Tumour biology: Policing of oncogene activity by p53

31 March 2020

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

31 March 2020

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p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress

31 March 2020

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p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

31 March 2020

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Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis

31 March 2020

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p53-independent functions of the p19(ARF) tumor suppressor

31 March 2020

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

31 March 2020

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

31 March 2020

1 reference

p63 and p73 in human cancer: defining the network

31 March 2020

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

2 references

31 March 2020

12 December 2020

p63 and p73 are not required for the development and p53-dependent apoptosis of T cells

1 reference

p63 protects the female germ line during meiotic arrest

31 March 2020

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DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

31 March 2020

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Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

31 March 2020

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

31 March 2020

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Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

31 March 2020

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The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

31 March 2020

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

31 March 2020

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beta-tting on p63 as a metastatic suppressor.

31 March 2020

1 reference

p53 ubiquitination: Mdm2 and beyond

31 March 2020

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

31 March 2020

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

31 March 2020

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

31 March 2020

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The p53-mdm-2 autoregulatory feedback loop

31 March 2020

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Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

31 March 2020

1 reference

MDM2 and MDM4: p53 regulators as targets in anticancer therapy

31 March 2020

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

31 March 2020

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

31 March 2020

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Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

31 March 2020

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

31 March 2020

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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

31 March 2020

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

31 March 2020

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A dynamic role of HAUSP in the p53-Mdm2 pathway

31 March 2020

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Critical role for Daxx in regulating Mdm2

31 March 2020

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

31 March 2020

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Molecular recognition of p53 and MDM2 by USP7/HAUSP

31 March 2020

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Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation

31 March 2020

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The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

31 March 2020

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Dual-site regulation of MDM2 E3-ubiquitin ligase activity

31 March 2020

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The central region of HDM2 provides a second binding site for p53.

31 March 2020

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

31 March 2020

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

31 March 2020

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ATM associates with and phosphorylates p53: mapping the region of interaction

31 March 2020

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The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

31 March 2020

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Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

31 March 2020

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

31 March 2020

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

31 March 2020

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

31 March 2020

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

31 March 2020

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

31 March 2020

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Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

31 March 2020

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DNA damage activates p53 through a phosphorylation-acetylation cascade

31 March 2020

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Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

31 March 2020

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

31 March 2020

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Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation

31 March 2020

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Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation

31 March 2020

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Phosphorylation of p53 serine 15 increases interaction with CBP

31 March 2020

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Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP

31 March 2020

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Differential recognition of phosphorylated transactivation domains of p53 by different p300 domains

31 March 2020

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Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

31 March 2020

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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

31 March 2020

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Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

31 March 2020

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

31 March 2020

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Hypophosphorylation of Mdm2 augments p53 stability

31 March 2020

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p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.

31 March 2020

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Defining the molecular basis of Arf and Hdm2 interactions

31 March 2020

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Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

31 March 2020

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Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

31 March 2020

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12 December 2020

p53 and human cancer: the first ten thousand mutations.

1 reference

12 December 2020

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12 December 2020

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

1 reference

12 December 2020

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

1 reference

12 December 2020

Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

1 reference

12 December 2020

The p16INK4a/CDKN2A tumor suppressor and its relatives.

1 reference

12 December 2020

p63 and p73: roles in development and tumor formation

1 reference

12 December 2020

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

1 reference

12 December 2020

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2716

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21 August 2017

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