Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells (Q28288888)

2

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A Krämer

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K Sommer

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F Rödel

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K Strebhardt

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J Yuan

Activation of p53 in cervical carcinoma cells by small molecules.

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language of work or name

English

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publication date

14 October 2010

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published in

Oncogene

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volume

29

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issue

41

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page(s)

5591-603

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cites work

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Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells

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Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol

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Awakening guardian angels: drugging the p53 pathway

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Elevation of cyclin B1, active cdc2, and HuR in cervical neoplasia with human papillomavirus type 18 infection.

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Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor

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Phosphorylation studies on rat p53 using the baculovirus expression system. Manipulation of the phosphorylation state with okadaic acid and influence on DNA binding

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The ARF tumour suppressor

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

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Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

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Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1).

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The complexity of p53 stabilization and activation

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Activation of p53 by roscovitine-mediated suppression of MDM2 expression

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Short version of the German evidence-based Guidelines for prophylactic vaccination against HPV-associated neoplasia

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Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta

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E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells

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Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1.

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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INK4a/ARF: a multifunctional tumor suppressor locus

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

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CDK9 phosphorylates p53 on serine residues 33, 315 and 392

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