STAT3 as a therapeutic target in head and neck cancer (Q28299368)

Expert Opinion on Biological Therapy

Europe PubMed Central

title

STAT3 as a therapeutic target in head and neck cancer (English)

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head and neck carcinoma

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Rebecca J Leeman

1

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Vivian Wai Yan Lui

series ordinal

2

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Jennifer Rubin Grandis

series ordinal

3

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language of work or name

English

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publication date

March 2006

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published in

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volume

6

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issue

3

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page(s)

231-41

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cites work

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

20 April 2017

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Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor

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Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

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STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

20 April 2017

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Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

20 April 2017

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A road map for those who don't know JAK-STAT

20 April 2017

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Specific inhibition of Stat3 signal transduction by PIAS3

20 April 2017

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https://api.crossref.org/works/10.1517/14712598.6.3.231

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction

20 April 2017

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https://api.crossref.org/works/10.1517/14712598.6.3.231

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

20 April 2017

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A new protein containing an SH2 domain that inhibits JAK kinases

20 April 2017

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https://api.crossref.org/works/10.1517/14712598.6.3.231

Structure and function of a new STAT-induced STAT inhibitor

20 April 2017

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https://api.crossref.org/works/10.1517/14712598.6.3.231

Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14712598.6.3.231

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

20 April 2017

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https://api.crossref.org/works/10.1517/14712598.6.3.231

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14712598.6.3.231

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

20 April 2017

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https://api.crossref.org/works/10.1517/14712598.6.3.231

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14712598.6.3.231

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

20 April 2017

1 reference

https://api.crossref.org/works/10.1517/14712598.6.3.231

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

20 April 2017

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https://api.crossref.org/works/10.1517/14712598.6.3.231

STATs and gene regulation

20 April 2017

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https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Stats: transcriptional control and biological impact

20 April 2017

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20 April 2017

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20 April 2017

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Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

20 April 2017

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Advances in cytokine signaling: the role of Jaks and STATs

21 January 2018

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JAKs and STATs branch out.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Jaks and Stats in signaling by the cytokine receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Jak-STAT signaling induced by the v-abl oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Are STATS arginine-methylated?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

STAT proteins: From normal control of cellular events to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Stat3 activation is required for cellular transformation by v-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Stat3 regulates genes common to both wound healing and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Targeting epidermal growth factor receptor in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Negative regulation of the JAK/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Negative regulation of cytokine signaling: STAT-induced STAT inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Suppressors of cytokine signalling: SOCS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Modulation of STAT signaling by STAT-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Antiproliferative activity of G-rich oligonucleotides correlates with protein binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Targeting Stat3 in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Rational drug design of G-quartet DNA as anti-cancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Oligonucleotides as anticancer agents: from the benchside to the clinic and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Dual blockade of cyclic AMP response element- (CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide. gene-specific inhibition of tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

STAT3 is required for the gp130-mediated full activation of the c-myc gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Association of Stat3-dependent transcriptional activation of p19INK4D with IL-6-induced growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231

Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.6.3.231