Small molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent update (Q28300334)

1

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Ekambaram Shanthi

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Mudeenahally H Krishna

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Jegatheesan Sooriya Kumar

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Vellarkad N Viswanadhan

Expert Opinion on Therapeutic Patents

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language of work or name

English

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publication date

January 2014

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published in

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volume

24

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issue

1

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page(s)

5-17

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cites work

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Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode

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The serine/threonine kinase Pim-1

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Pim kinases in cancer: diagnostic, prognostic and treatment opportunities

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

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Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase

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Why Target PIM1 for Cancer Diagnosis and Treatment?

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For better or for worse: the role of Pim oncogenes in tumorigenesis

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PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

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PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells

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Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

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7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity

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Using insights into Pim1 structure to design new anticancer drugs

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Insights from Pim1 structure for anti-cancer drug design.

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Pim kinase inhibitors: a survey of the patent literature

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Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

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PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas

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Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice

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Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

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Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase.

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Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma

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Structure and substrate specificity of the Pim-1 kinase

21 January 2018

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21 January 2018

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