Differential regulation and properties of MAPKs (Q28301932)

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

Europe PubMed Central

title

Differential regulation and properties of MAPKs (English)

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author name string

M Raman

series ordinal

1

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W Chen

series ordinal

2

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M H Cobb

series ordinal

3

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language of work or name

English

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publication date

14 May 2007

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published in

Oncogene

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volume

26

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page(s)

3100-12

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issue

22

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cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Protein tyrosine phosphatases in the human genome

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3)

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Identification of stathmin as a novel substrate for p38 delta

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

IQGAP1 binds ERK2 and modulates its activity

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

The structure of mitogen-activated protein kinase p38 at 2.1-A resolution

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

A mammalian scaffold complex that selectively mediates MAP kinase activation

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Crystal structure of p38 mitogen-activated protein kinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210392

A central role for JNK in obesity and insulin resistance

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

A conserved docking motif in MAP kinases common to substrates, activators and regulators

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Specificity determinants in MAPK signaling to transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Mechanism of p38 MAP kinase activation in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Protein phosphatase 5 in signal transduction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Hypoxia differentially regulates the mitogen- and stress-activated protein kinases. Role of Ca2+/CaM in the activation of MAPK and p38 gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Regulation of Raf-1 by direct feedback phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Mxi2, a splice variant of p38 stress-activated kinase, is a distal nephron protein regulated with kidney ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Signal transduction through MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

BuCy RAFs drive cells into MEK addiction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Identification of a cytoplasmic-retention sequence in ERK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Extracellular signals and scores of phosphatases: all roads lead to MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Docking domains and substrate-specificity determination for MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

ERK1c regulates Golgi fragmentation during mitosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Sef is a spatial regulator for Ras/MAP kinase signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

ERK2 enters the nucleus by a carrier-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Exip, a splicing variant of p38alpha, participates in interleukin-1 receptor proximal complex and downregulates NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Docking interactions induce exposure of activation loop in the MAP kinase ERK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210392

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210392

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

252075

1018703780

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Fatcat ID

release_vgwhtoh4bnbslk2mwb5mppypzq

0 references

252075

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference