Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases (Q28303760)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15665253%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases (English)

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7 January 2020

1

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7 January 2020

Michael W Pennington

2

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ShK toxin: history, structure and therapeutic applications for autoimmune diseases

7 January 2020

11

object named as

K George Chandy

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7 January 2020

author name string

Heike Wulff

3

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7 January 2020

Satendra Singh

4

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7 January 2020

Daniel Nugent

5

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7 January 2020

George Crossley

6

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7 January 2020

Ilya Khaytin

7

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7 January 2020

Chao-Yin Chen

9

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7 January 2020

George A Gutman

10

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7 January 2020

Peter A Calabresi

8

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7 January 2020

language of work or name

English

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publication date

21 January 2005

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7 January 2020

published in

Molecular Pharmacology

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7 January 2020

volume

67

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7 January 2020

issue

4

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7 January 2020

page(s)

1369-1381

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Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes

7 January 2020

cites work

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Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

20 March 2017

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20 March 2017

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Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels

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20 March 2017

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Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3

20 March 2017

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ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

20 March 2017

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Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo

20 March 2017

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A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity

20 March 2017

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Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain

20 March 2017

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Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom

20 March 2017

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Voltage-gated potassium channels are required for human T lymphocyte activation

20 March 2017

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Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology

20 March 2017

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K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom.

7 April 2017

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Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.

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29 September 2017

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Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.

29 September 2017

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Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators

29 September 2017

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3-Alkyl- and 3-aryl-7H-furo[3,2-g]chromen-7-ones as blockers of the voltage-gated potassium channel Kv1.3.

29 September 2017

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Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity

29 September 2017

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Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease

29 September 2017

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29 September 2017

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Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile

29 September 2017

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Protein Surface Recognition by Rational Design: Nanomolar Ligands for Potassium Channels

29 September 2017

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A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes

29 September 2017

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29 September 2017

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Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties

29 September 2017

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GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

29 September 2017

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Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).

29 September 2017

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T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis

29 September 2017

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The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis

29 September 2017

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Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.

29 September 2017

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Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24.

29 September 2017

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Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

29 September 2017

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WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels

29 September 2017

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HERG-like K+ channels in microglia.

29 September 2017

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Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells

29 September 2017

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Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom

29 September 2017

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An essential binding surface for ShK toxin interaction with rat brain potassium channels

29 September 2017

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Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines

29 September 2017

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Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis.

29 September 2017

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CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen

2 June 2018

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2 June 2018

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Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation

2 June 2018

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Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species

2 June 2018

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A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis

2 June 2018

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Flow cytometric characterization of lesional T cells in psoriasis: intracellular cytokine and surface antigen expression indicates an activated, memory/effector type 1 immunophenotype.

2 June 2018

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UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation

27 November 2018

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Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation

27 November 2018

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Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology.

27 November 2018

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Comparative analysis of CD45RA- and CD45RO-positive CD4+T cells in peripheral blood, synovial fluid, and synovial tissue in patients with rheumatoid arthritis and osteoarthritis.

27 November 2018

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Synthesis of phosphotyrosine-containing peptides by the solid-phase method. A re-examination of the use of Boc-Tyr(PO3Bzl2)-OH

27 November 2018

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12 December 2020

Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3.

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12 December 2020

Binding of correolide to K(v)1 family potassium channels. Mapping the domains of high affinity interaction

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12 December 2020

Transformation of arylmethylamines into alpha-aminophosphonic acids via metalated phosphoramidates: rearrangement of partly configurationally stable N-phosphorylated alpha-aminocarbanions

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12 December 2020

Racemization-free synthesis of C-terminal cysteine-peptide using 2-chlorotrityl resin

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12 December 2020

Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone

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12 December 2020

Potent Kv1.3 inhibitors from correolide-modification of the C18 position

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12 December 2020

Identifiers

DOI

10.1124/MOL.104.008193

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15665253%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15665253%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

2 references