NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage (Q28304255)

2

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Hideki Yamamoto

3

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Takayuki Hanamoto

4

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Hironobu Kikuchi

5

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Kazushige Furuya

6

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Masahiro Asaka

7

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Domenico Delia

8

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Akira Nakagawara

Journal of Biological Chemistry

9

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language of work or name

English

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publication date

3 August 2007

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published in

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volume

282

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issue

31

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page(s)

22993-3004

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cites work

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

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NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

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NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

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MDC1 regulates DNA-PK autophosphorylation in response to DNA damage

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

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Nucleolar Arf sequesters Mdm2 and activates p53

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NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events

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ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage

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