Phosphorylation site interdependence of human p53 post-translational modifications in response to stress (Q44513266)

3 December 2017

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress (English)

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3 December 2017

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Yuichiro Higashimoto

3

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Albert J Fornace

object named as

Albert J Fornace

6

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author name string

Shin'ichi Saito

1

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3 December 2017

Connie Chao

4

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3 December 2017

Yang Xu

5

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3 December 2017

Ettore Appella

7

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3 December 2017

Carl W Anderson

8

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3 December 2017

Hiroshi Yamaguchi

2

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3 December 2017

language of work or name

English

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publication date

14 July 2003

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Journal of Biological Chemistry

3 December 2017

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3 December 2017

278

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3 December 2017

39

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3 December 2017

37536-37544

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Post-translational modifications and activation of p53 by genotoxic stresses

3 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

p53-dependent cell cycle control: response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Mutation of phosphoserine 389 affects p53 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M305135200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M305135200

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Acetylation of p53 inhibits its ubiquitination by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Cisplatinum and taxol induce different patterns of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Mutation of mouse p53 Ser23 and the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Multisite phosphorylation provides sophisticated regulation of transcription factors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M305135200

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Phosphorylation of human p53 on Thr-55.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

p53 contains large unstructured regions in its native state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305135200

21 January 2018

Identifiers

DOI

10.1074/JBC.M305135200

1 reference

3 December 2017

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