Polymorphisms of CYP2A6 and its practical consequences (Q28362536)

Europe PubMed Central

title

Polymorphisms of CYP2A6 and its practical consequences (English)

0 references

author name string

H Raunio

1

0 references

A Rautio

2

0 references

H Gullstén

3

0 references

O Pelkonen

British Journal of Clinical Pharmacology

4

0 references

language of work or name

English

0 references

publication date

October 2001

0 references

published in

0 references

volume

52

0 references

issue

4

0 references

page(s)

357-63

0 references

cites work

Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

CYP2A6: a human coumarin 7-hydroxylase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Expression and alternative splicing of the cytochrome P-450 CYP2A7

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Expression of CYP2A genes in human liver and extrahepatic tissues.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Cytochrome P-450 3A4: regulation and role in drug metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Mechanism-based inactivation of P450 2A6 by furanocoumarins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

The inhibition of CYP enzymes in mouse and human liver by pilocarpine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Characterization of multiple products of cytochrome P450 2A6-catalyzed cotinine metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Genetic variation of CYP2A6, smoking, and risk of cancer.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Nicotine metabolism defect reduces smoking

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Metabolism-dependent activation and toxicity of chemicals in nasal glands.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Expression of CYP2A genes in rodent and human nasal mucosa.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Metabolic interactions of methoxsalen and coumarin in humans and mice

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.0306-5251.2001.01500.X

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.0306-5251.2001.01500.X

Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014580

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

27 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.0306-5251.2001.01500.X

21 January 2018

1 reference

12 December 2020

Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: identification of CYP2A6 as a major catalyst

1 reference

12 December 2020

Role of human cytochrome P4502A6 in C-oxidation of nicotine

1 reference

12 December 2020

Inhibition of coumarin 7-hydroxylase activity in human liver microsomes.

1 reference

12 December 2020

Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population

1 reference

12 December 2020

CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis

1 reference

12 December 2020

Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells

1 reference

12 December 2020

Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity

1 reference

12 December 2020

Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine

1 reference

12 December 2020

Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes

1 reference

12 December 2020

Interindividual variability of coumarin 7-hydroxylation in healthy volunteers

1 reference

12 December 2020

In vitro-in vivo correlations of human (s)-nicotine metabolism

1 reference

12 December 2020

Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram

1 reference

12 December 2020

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes

1 reference

12 December 2020

CYP2A6 gene deletion reduces susceptibility to lung cancer

1 reference

12 December 2020

10.1046/J.0306-5251.2001.01500.X

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

11678779

1 reference