Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS) (Q28365993)

9

Y Shoenfeld

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Miri Blank

8

M Blank

0 references

Joab Chapman

10

J Chapman

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Aviva Katzav

1

A Katzav

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author name string

Y Kloog

2

0 references

H Niv

4

0 references

D M Karussis

5

0 references

N Wang

6

0 references

R Rabinowitz

Clinical and Experimental Immunology

7

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language of work or name

English

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publication date

December 2001

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published in

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volume

126

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issue

3

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page(s)

570-7

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cites work

Signal transduction by lymphocyte antigen receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Novel Ras antagonist blocks human melanoma growth

24 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Stringent structural requirements for anti-Ras activity of S-prenyl analogues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Dislodgment and accelerated degradation of Ras.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Function and regulation of ras.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

The regulation and function of p21ras during T-cell activation and growth.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Comparison of in vitro and in vivo mitogenic and polyclonal antibody and autoantibody responses to peptidoglycan, LPS, protein A, PWM, PHA and Con A in normal and autoimmune mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Experimental and induced animal models of systemic lupus erythematosus and Sjögren's syndrome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

p21ras is modified by a farnesyl isoprenoid

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Signal transduction in T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Immunopharmacology: immunomodulation and immunotherapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Protooncogenes and autoimmunity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Animal models for nervous system disease in systemic lupus erythematosus

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

The complexity of signaling pathways activated by the BCR.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Lymphocyte activation in health and disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

GTPases in antigen receptor signalling

2 June 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2249.2001.01674.X

The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2249.2001.01674.X

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2249.2001.01674.X

Stimulation of p21 ras upon T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2249.2001.01674.X

Modulation of glomerular structure and function in murine lupus nephritis by methylprednisolone and cyclophosphamide.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1906212

Anti-intercellular adhesion molecule-1 (ICAM-1) antibody treatment prevents central and peripheral nervous system disease in autoimmune-prone mice

27 November 2018

1 reference

12 December 2020

Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4 CD8 T lymphocytes from MRL lpr mice

1 reference

12 December 2020

Serum glomerular binding activity is highly correlated with renal disease in MRL/lpr mice

1 reference

12 December 2020

Differential effects of anti-beta2-glycoprotein I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome

1 reference

12 December 2020

Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus

1 reference

12 December 2020

Reduction of mortality and lymphadenopathy in MRL-lpr/lpr mice treated with nonmitogenic anti-CD3 monoclonal antibody

1 reference

12 December 2020

Experimental models for antiphospholipid studies

1 reference

12 December 2020

Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice

1 reference

12 December 2020

Effect of long-term anti-CD4 or anti-CD8 treatment on the development of lpr CD4- CD8- double negative T cells and of the autoimmune syndrome in MRL-lpr/lpr mice

1 reference

12 December 2020

Cyclophosphamide-induced changes in the MRL-lpr/lpr mouse: effects upon cellular composition, immune function, and disease

1 reference

12 December 2020

Delineation of two defects responsible for T-cell hyporesponsiveness to concanavalin A in MRL congenic mice

1 reference

12 December 2020

Expression of heterozygous lpr gene in MRL mice. I. Defective T-cell reactivity and polyclonal B-cell activation

1 reference

12 December 2020

Down-regulation of autoantibody levels of cyclosporine and bromocriptine treatment in patients with uveitis

1 reference

12 December 2020