COPs and POPs: modulators of inflammasome activity (Q28387485)

A Shope Fibroma virus PYRIN-only protein modulates the host immune response

Europe PubMed Central

title

COPs and POPs: modulators of inflammasome activity (English)

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Christian Stehlik

1

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Andrea Dorfleutner

series ordinal

2

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language of work or name

English

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publication date

15 December 2007

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published in

Journal of Immunology

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volume

179

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issue

12

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page(s)

7993-8

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cites work

1 reference

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The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation

20 March 2017

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NALPs: a novel protein family involved in inflammation

20 March 2017

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

20 March 2017

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20 March 2017

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The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways

20 March 2017

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

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The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

20 March 2017

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20 March 2017

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Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis

20 March 2017

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ICEBERG: a novel inhibitor of interleukin-1beta generation

20 March 2017

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

20 March 2017

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20 March 2017

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

20 March 2017

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

20 March 2017

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

7 April 2017

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Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

7 April 2017

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7 April 2017

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Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release

29 September 2017

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Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

29 September 2017

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The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing

29 September 2017

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29 September 2017

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The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production

29 September 2017

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CATERPILLERs, pyrin and hereditary immunological disorders

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A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways

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Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

29 September 2017

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Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene

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29 September 2017

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MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.

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Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes

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12 December 2020

Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC

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Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients

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24 November 2022