Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger (Q28397100)

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English	Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger	scientific article

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scholarly article

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Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger (English)

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based on heuristic

inferred from title

Radovan Dvorsky

2

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1

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Dieter Häussinger

14

object named as

Dieter Häussinger

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author name string

Ehsan Amin

3

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Sarah L Risse

4

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Eyad K Fansa

5

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Si-Cai Zhang

6

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Mohamed S Taha

7

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Aziz R Gauhar

8

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Saeideh Nakhaei-Rad

9

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Claus Kordes

10

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Katja T Koessmeier

11

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Ion C Cirstea

12

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Monilola A Olayioye

13

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Mohammad R Ahmadian

15

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language of work or name

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publication date

7 March 2014

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Journal of Biological Chemistry

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289

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10

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6839-49

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Deleted in liver cancer protein family in human malignancies (Review)

1 reference

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Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)

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19 March 2017

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

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E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases

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Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

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19 March 2017

DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain

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19 March 2017

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

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19 March 2017

p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

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19 March 2017

Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1

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A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

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Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration

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19 March 2017

DLC-1: a Rho GTPase-activating protein and tumour suppressor

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19 March 2017

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

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Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

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19 March 2017

Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver

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Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

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The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

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19 March 2017

High resolution crystal structures of the p120 RasGAP SH3 domain

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Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

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19 March 2017

Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity

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Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76

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Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins

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Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP

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Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation

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19 March 2017

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

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The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain

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19 March 2017

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

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p120RasGAP-mediated activation of c-Src is critical for oncogenic Ras to induce tumor invasion

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Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathway

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Rho GTPase-activating proteins in cell regulation

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p120 GAP modulates Ras activation of Jun kinases and transformation

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