Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background (Q28481297)

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387243

19 March 2017

Kirstyn Brunker

3

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Hideo Imamura

object named as

Hideo Imamura

4

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author name string

Sylke Müller

5

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Basudha Khanal

6

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Suman Rijal

7

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Jean-Claude Dujardin

8

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Graham H Coombs

PLoS Neglected Tropical Diseases

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language of work or name

English

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publication date

2012

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published in

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volume

6

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issue

2

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page(s)

e1514

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copyright license

Creative Commons Attribution 2.5 Generic

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on focus list of Wikimedia project

ScienceSource

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cites work

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

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Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden

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Molecular basis of antimony treatment in leishmaniasis

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Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

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Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma

19 March 2017

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Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic

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Sodium stibogluconate (Pentostam) potentiates oxidant production in murine visceral leishmaniasis and in human blood

19 March 2017

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Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?

19 March 2017

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qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data

6 April 2017

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Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex

7 April 2017

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Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?

29 September 2017

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Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis

29 September 2017

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Comparative gene expression analysis throughout the life cycle of Leishmania braziliensis: diversity of expression profiles among clinical isolates

29 September 2017

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Transcriptomics throughout the life cycle of Leishmania infantum: high down-regulation rate in the amastigote stage.

29 September 2017

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Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony

29 September 2017

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Proteophosphoglycan is differentially expressed in sodium stibogluconate-sensitive and resistant Indian clinical isolates of Leishmania donovani

29 September 2017

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Differential gene expression analysis in antimony-unresponsive Indian kala azar (visceral leishmaniasis) clinical isolates by DNA microarray.

29 September 2017

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Molecular mechanisms of antimony resistance in Leishmania

29 September 2017

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Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal

29 September 2017

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American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility?

29 September 2017

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The competitive cost of antibiotic resistance in Mycobacterium tuberculosis

29 September 2017

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Chemotherapy in the treatment and control of leishmaniasis

29 September 2017

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Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages

29 September 2017

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Perspective: Sign epistasis and genetic constraint on evolutionary trajectories

29 September 2017

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Refractoriness to the treatment of sodium stibogluconate in Indian kala-azar field isolates persist in in vitro and in vivo experimental models

29 September 2017

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Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

29 September 2017

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Progress in the treatment of a neglected infectious disease: visceral leishmaniasis

29 September 2017

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Antimony Uptake Systems in the Protozoan Parasite Leishmania and Accumulation Differences in Antimony-Resistant Parasites

29 September 2017

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Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major

29 September 2017

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Thiol-based redox metabolism of protozoan parasites

29 September 2017

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The Parasite-Specific Trypanothione Metabolism of Trypanosoma and Leishmania

29 September 2017

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Glutathione-induced conversion of pentavalent antimony to trivalent antimony in meglumine antimoniate

29 September 2017

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Glutathione and trypanothione in parasitic hydroperoxide metabolism

29 September 2017

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Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

29 September 2017

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An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae

29 September 2017

1 reference

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Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.

29 September 2017

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Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials

29 September 2017

1 reference

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Metabolism and functions of trypanothione in the Kinetoplastida

29 September 2017

1 reference

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Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

29 September 2017

1 reference

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In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289598

Sodium stibogluconate resistance in Leishmania donovani correlates with greater tolerance to macrophage antileishmanial responses and trivalent antimony therapy

2 June 2018

1 reference

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pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

2 June 2018

1 reference

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Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289598

Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.

2 June 2018

1 reference

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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289598

Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata.

2 June 2018

1 reference

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A developmentally regulated cysteine proteinase gene of Leishmania mexicana

2 June 2018

1 reference

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Antigenic variation in syringe passaged populations of Trypanosoma (Trypanozoon) brucei. II. Comparative studies on two antigenic-type collections

2 June 2018

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Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani

2 June 2018

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Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome?

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Overexpression of histone H2A modulates drug susceptibility in Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Antigen genes for molecular epidemiology of leishmaniasis: polymorphism of cysteine proteinase B and surface metalloprotease glycoprotein 63 in the Leishmania donovani complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Ovothiol and trypanothione as antioxidants in trypanosomatids

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Generation of Leishmania donovani axenic amastigotes: their growth and biological characteristics

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Learning monotonic genotype-phenotype maps

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Reduction of pentavalent antimony by trypanothione and formation of a binary and ternary complex of antimony(III) and trypanothione.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001514

Characterization of natural antimony resistance in Leishmania donovani isolates.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289598

Role of aquaglyceroporin (AQP1) gene and drug uptake in antimony-resistant clinical isolates of Leishmania donovani

27 November 2018

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12 December 2020

Glutathione protects macrophages and Leishmania major against nitric oxide-mediated cytotoxicity

1 reference

12 December 2020

Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs

1 reference

12 December 2020

The fitness of antimony-resistant Leishmania parasites: lessons from the field

1 reference

12 December 2020

Resistance to antimony and treatment failure in human Leishmania (Viannia) infection

1 reference

12 December 2020

Mechanism of metalloid-induced death in Leishmania spp.: role of iron, reactive oxygen species, Ca2+, and glutathione

1 reference

12 December 2020

10.1371/JOURNAL.PNTD.0001514

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

5112082

OpenCitations bibliographic resource ID

5112082

1 reference