The Parasite-Specific Trypanothione Metabolism of Trypanosoma and Leishmania (Q33966094)

30 July 2017

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title

The parasite-specific trypanothione metabolism of trypanosoma and leishmania (English)

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30 July 2017

The Parasite-Specific Trypanothione Metabolism of Trypanosoma and Leishmania (English)

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3 January 2024

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3 January 2024

author name string

Heide Schmidt

3

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30 July 2017

R. Luise Krauth-Siegel

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12751784

3 January 2024

Svea K. Meiering

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12751784

3 January 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12751784

3 January 2024

publication date

1 April 2003

1 reference

full work available at URL

30 July 2017

https://www.degruyter.com/document/doi/10.1515/BC.2003.062/pdf

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3 January 2024

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30 July 2017

volume

384

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30 July 2017

issue

4

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30 July 2017

page(s)

539-549

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Molecular characterization of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei: comparison with other flavoprotein disulphide oxidoreductases with respect to substrate specificity and catalytic mechanism

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

21 January 2018

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Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part

21 January 2018

1 reference

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Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes

21 January 2018

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Ovothiol and trypanothione as antioxidants in trypanosomatids

21 January 2018

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Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis

21 January 2018

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Redox potentials of glutaredoxins and other thiol-disulfide oxidoreductases of the thioredoxin superfamily determined by direct protein-protein redox equilibria

21 January 2018

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Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

21 January 2018

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Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2003.062

Putrescine and spermidine transport in Leishmania.

21 January 2018

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Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription

21 January 2018

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Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

21 January 2018

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Estimation of individual types of glutathione peroxidases

21 January 2018

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Trypanothione-dependent peroxide metabolism in Trypanosoma cruzi different stages.

21 January 2018

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Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum

21 January 2018

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Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent Antimonials

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2003.062

The therapeutic potential of inhibitors of the trypanothione cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Cloning, sequencing and expression of ribonucleotide reductase R2 from Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Metabolism and functions of trypanothione in the Kinetoplastida

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2003.062

Glutathione: Its reaction with NADP and its oxidation-reduction potential

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2003.062

Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

A second class of peroxidases linked to the trypanothione metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Cloning and characterization of the R1 and R2 subunits of ribonucleotide reductase from Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Structures of tryparedoxins revealing interaction with trypanothione

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Active site of trypanothione reductase. A target for rational drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Identification and characterisation of a functional peroxidoxin from Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Procyclic Trypanosoma brucei cell lines deficient in ornithine decarboxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Characterization of Trypanosoma brucei gamma-glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione (diglutathionylspermidine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Sequence, heterologous expression and functional characterization of a novel tryparedoxin from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Activation of active-site cysteine residues in the peroxiredoxin-type tryparedoxin peroxidase of Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Characterization of Escherichia coli thioredoxin variants mimicking the active-sites of other thiol/disulfide oxidoreductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Identification and functional characterization of thioredoxin from Trypanosoma brucei brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Catalytic properties, thiol pK value, and redox potential of Trypanosoma brucei tryparedoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Roles of thiol-redox pathways in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Genetic analysis of spermidine synthase from Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Silencing of the thioredoxin gene in Trypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Thiol metabolism of the trypanosomatids as potential drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanosomal antioxidants and emerging aspects of redox regulation in the trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Dual function of the selenoprotein PHGPx during sperm maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

The biosynthesis of ovothiol A (N-methyl-4-mercaptohistidine). Identification of S-(4'-L-histidyl)-L-cysteine sulfoxide as an intermediate and the products of the sulfoxide lyase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Thioredoxin reductase two modes of catalysis have evolved

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Ornithine Decarboxylase Gene Deletion Mutants ofLeishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.062

Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi

21 January 2018

14

1 reference

Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-l-methionine

3 January 2024

16

1 reference

Tryparedoxin and tryparedoxin peroxidase

3 January 2024

30

1 reference

Regulation of the intracellular pH in the protozoan parasite Trypanosoma brucei brucei

3 January 2024

31

1 reference

Complete amino acid sequence of yeast thioltransferase (glutaredoxin)

3 January 2024

32

1 reference

Catalytic characteristics of tryparedoxin

3 January 2024

34

1 reference

Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae

3 January 2024

37

1 reference

Vitamin C and genomic stability

3 January 2024

38

1 reference

Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

3 January 2024

47

1 reference

Convenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata

3 January 2024

50

1 reference

Mimicking the active site of protein disulfide-isomerase by substitution of proline 34 in Escherichia coli thioredoxin

3 January 2024

51

1 reference

Reduction of dehydroascorbate by trypanothione

3 January 2024

52

1 reference

Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania

3 January 2024

58

1 reference

Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli

3 January 2024

62

1 reference

Glutathione S-transferase pi in an arsenic-resistant Chinese hamster ovary cell line

3 January 2024

63

1 reference

Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z

3 January 2024

69

1 reference

Glutathione-dependent activities of Trypanosoma cruzi p52 makes it a new member of the thiol:disulphide oxidoreductase family

3 January 2024

72

1 reference

Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania.

3 January 2024

75

1 reference

Trypanosomatid hydrogen peroxide [corrected] metabolism

3 January 2024

78

1 reference

Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

3 January 2024

85

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Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification, and characterization

3 January 2024

94

1 reference

The catalytic mechanism of the glutathione-dependent dehydroascorbate reductase activity of thioltransferase (glutaredoxin)

3 January 2024

101

1 reference

3 January 2024

Identifiers

DOI

10.1515/BC.2003.062

1 reference

30 July 2017

1 reference