A spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell culture (Q28484490)

2

Kavitha

Akula

1 reference

29 October 2023

Alla Arzumanyan

3

Alla

Arzumanyan

1 reference

29 October 2023

Jennifer Alleva

4

Jennifer

Alleva

1 reference

29 October 2023

Marcus Jackson

5

Marcus

Jackson

1 reference

29 October 2023

Eugeney Bichenkov

6

Eugeney

Bichenkov

1 reference

29 October 2023

Joel B Sheffield

7

Joel B

Sheffield

1 reference

29 October 2023

Mark A Feitelson

8

Mark A

Feitelson

1 reference

29 October 2023

Christian E Schafmeister

9

Christian E

Creative Commons Attribution 4.0 International

Schafmeister

1 reference

29 October 2023

language of work or name

English

0 references

publication date

2012

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published in

PLOS One

0 references

volume

7

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issue

10

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page(s)

e45948

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copyright license

start time

18 October 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

19 March 2017

1 reference

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

19 March 2017

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Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.

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1 reference

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Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics

29 September 2017

1 reference

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Synthetic mimetics of protein secondary structure domains

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In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX

29 September 2017

1 reference

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Beta-peptides with improved affinity for hDM2 and hDMX.

29 September 2017

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

29 September 2017

1 reference

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Unlocking the Mdm2-p53 loop: ubiquitin is the key.

29 September 2017

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Targeting protein-protein interactions: lessons from p53/MDM2.

29 September 2017

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29 September 2017

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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

29 September 2017

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29 September 2017

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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

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Regulation of P53 stability in p53 mutated human and mouse hepatoma cells

29 September 2017

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Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

2 June 2018

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High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

27 November 2018

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Exploiting an inherent neighboring group effect of alpha-amino acids to synthesize extremely hindered dipeptides

27 November 2018

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Shape-programmable macromolecules

27 November 2018

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A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation

27 November 2018

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Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

27 November 2018

1 reference

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Solid-phase synthesis of functionalized bis-peptides

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12 December 2020

Residue-based control of helix shape in β-peptide oligomers

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12 December 2020

Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions

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12 December 2020

Determinants of specificity of MDM2 for the activation domains of p53 and p65: proline27 disrupts the MDM2-binding motif of p53

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12 December 2020

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

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12 December 2020

Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0045948

Identifiers

DOI

1 reference

3988903

ADS bibcode

2012PLoSO...745948B

0 references

3988903

1 reference

1 reference

1 reference