Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 (Q28507338)

GOA release 2020-03-11

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Klaus Rajewsky

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Laurie Glimcher

6

object named as

Laurie H. Glimcher

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24 January 2017

Neal N. Iwakoshi

1

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24 January 2017

Ann-Hwee Lee

2

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24 January 2017

Prasanth Vallabhajosyula

3

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24 January 2017

Kevin L. Otipoby

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

4

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24 January 2017

language of work or name

English

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publication date

1 April 2003

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24 January 2017

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24 January 2017

4

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24 January 2017

321–329

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24 January 2017

4

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24 January 2017

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7 January 2021

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

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A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

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The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

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Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

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7 January 2021

Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response

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7 January 2021

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

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7 January 2021

tRNA ligase is required for regulated mRNA splicing in the unfolded protein response

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7 January 2021

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

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7 January 2021

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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7 January 2021

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

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7 January 2021

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

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7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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7 January 2021

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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7 January 2021

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

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7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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7 January 2021

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

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7 January 2021

In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis.

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7 January 2021

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

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7 January 2021

Plasma cell differentiation requires the transcription factor XBP-1

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7 January 2021

Plasma cells: finding new light at the end of B cell development

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7 January 2021

Activation of an unfolded protein response during differentiation of antibody-secreting B cells.

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7 January 2021

A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain gene

1 reference

7 January 2021

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

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7 January 2021

Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation

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7 January 2021

Specific dual effect of cycloheximide on B lymphocyte apoptosis: involvement of CPP32/caspase-3

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7 January 2021

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

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7 January 2021

Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes

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7 January 2021

Unconventional splicing of HAC1/ERN4 mRNA required for the unfolded protein response. Sequence-specific and non-sequential cleavage of the splice sites

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7 January 2021

Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway

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7 January 2021

Interleukin 6 and plasma cell neoplasias

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7 January 2021

The IL-4 receptor: signaling mechanisms and biologic functions

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7 January 2021

Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression.

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7 January 2021

A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells

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7 January 2021

Immune responses of IL-4, IL-5, IL-6 deficient mice.

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7 January 2021

IL-6 transgenic mouse model for extraosseous plasmacytoma

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7 January 2021

The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain

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7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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7 January 2021

Immunoglobulin heavy chain binding protein

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7 January 2021

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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7 January 2021

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

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7 January 2021

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

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7 January 2021

A novel transcription factor, T-bet, directs Th1 lineage commitment

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7 January 2021

Sequential involvement of NFAT and Egr transcription factors in FasL regulation

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7 January 2021

Identifiers

DOI

10.1038/NI907

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1369911

1031283799

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1369911

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference