Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice (Q28507519)

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12 November 2019

title

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice (English)

2 references

24 January 2017

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12 November 2019

1 reference

GOA release 2020-03-11

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1

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12 November 2019

Gijsbertus van der Horst

3

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12 November 2019

Klaus Rajewsky

14

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12 November 2019

author name string

Y Fukita

2

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12 November 2019

J de Boer

4

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12 November 2019

G Weeda

5

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12 November 2019

J Essers

6

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12 November 2019

N de Wind

7

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12 November 2019

B P Engelward

8

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12 November 2019

L Samson

9

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12 November 2019

S Verbeek

10

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12 November 2019

J M de Murcia

11

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12 November 2019

G de Murcia

12

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12 November 2019

H te Riele

13

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12 November 2019

language of work or name

English

0 references

publication date

1 June 1998

2 references

24 January 2017

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Journal of Experimental Medicine

12 November 2019

published in

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12 November 2019

volume

187

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12 November 2019

issue

11

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12 November 2019

page(s)

1735-1743

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A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy

12 November 2019

cites work

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Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

19 March 2017

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Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

19 March 2017

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hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

19 March 2017

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Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.

19 March 2017

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The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor

19 March 2017

1 reference

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

19 March 2017

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Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells

19 March 2017

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ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes

19 March 2017

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B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes

19 March 2017

1 reference

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Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

29 September 2017

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A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy

29 September 2017

1 reference

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Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches

29 September 2017

1 reference

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The mechanism of somatic hypermutation studied with transgenic and transfected target genes

29 September 2017

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The molecular basis of somatic hypermutation of immunoglobulin genes

29 September 2017

1 reference

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Clonal selection and learning in the antibody system

29 September 2017

1 reference

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Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing

29 September 2017

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Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair

29 September 2017

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

29 September 2017

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It was a very good year for DNA repair

29 September 2017

1 reference

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Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

29 September 2017

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Transcription-coupled repair and human disease

29 September 2017

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Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

29 September 2017

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High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

29 September 2017

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Somatic hypermutation: how many mechanisms diversify V region sequences?

29 September 2017

1 reference

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29 September 2017

Somatic hypermutation

1 reference

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Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

29 September 2017

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Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development.

29 September 2017

1 reference

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The dynamic nature of the antibody repertoire

29 September 2017

1 reference

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Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?

29 September 2017

1 reference

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Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loop

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

29 September 2017

1 reference

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Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Germinal centres in T-cell-dependent antibody responses

29 September 2017

1 reference

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Analysis of the repertoire of anti-(4-hydroxy-3-nitro-phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

A new view of V(D)J recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Direct association between the yeast Rad51 and Rad54 recombination proteins.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH): evidence for the existence of a transcription syndrome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Zonal distribution of immunoglobulin-synthesizing cells within the germinal centre: an in situ hybridization and immunohistochemical study

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212309

Generation of immunoglobulin variable gene diversity.

2 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.187.11.1735

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.187.11.1735

Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.187.11.1735

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.187.11.1735

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.187.11.1735

Origin of Antibody Variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.187.11.1735

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

21 January 2018

1 reference

12 December 2020

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

12 December 2020

Two Pathways for Base Excision Repair in Mammalian Cells

1 reference

12 December 2020

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms

1 reference

12 December 2020

Introduction: what mechanism(s) drive hypermutation?

1 reference

12 December 2020

Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)

1 reference

12 December 2020

Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.187.11.1735

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9607915%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9607915%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

2 references

24 January 2017