Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein (Q28505917)

24 January 2017

title

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein (English)

1 reference

24 January 2017

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GOA release 2020-03-11

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Q. H. Phung

1

1 reference

24 January 2017

D. B. Winter

2

1 reference

24 January 2017

A. Cranston

3

1 reference

24 January 2017

R. E. Tarone

4

1 reference

24 January 2017

V. A. Bohr

5

1 reference

24 January 2017

R. Fishel

6

1 reference

24 January 2017

P. J. Gearhart

7

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24 January 2017

language of work or name

English

0 references

publication date

1 June 1998

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Journal of Experimental Medicine

24 January 2017

published in

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24 January 2017

volume

187

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24 January 2017

issue

11

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24 January 2017

page(s)

1745–1751

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Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

24 January 2017

cites work

1 reference

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Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

19 March 2017

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Female embryonic lethality in mice nullizygous for both Msh2 and p53

19 March 2017

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hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

19 March 2017

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Instability and decay of the primary structure of DNA

19 March 2017

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

19 March 2017

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GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

19 March 2017

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Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

19 March 2017

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MSH2 deficient mice are viable and susceptible to lymphoid tumours

19 March 2017

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Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

19 March 2017

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Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

19 March 2017

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Mismatch repair in replication fidelity, genetic recombination, and cancer biology

19 March 2017

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Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

7 April 2017

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Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers

29 September 2017

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Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

29 September 2017

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29 September 2017

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Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

29 September 2017

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An immunoglobulin mutator that targets G.C base pairs

29 September 2017

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Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity

29 September 2017

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Clusters of point mutations are found exclusively around rearranged antibody variable genes

29 September 2017

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Patterns of somatic mutations in immunoglobulin variable genes

29 September 2017

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Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response

29 September 2017

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Molecular basis of base substitution hotspots in Escherichia coli

29 September 2017

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29 September 2017

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2 June 2018

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Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability

2 June 2018

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Mismatch Repair Deficiency in Phenotypically Normal Human Cells

2 June 2018

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mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

2 June 2018

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What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?

2 June 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

2 June 2018

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Locus-specific somatic hypermutation in germinal centre T cells

2 June 2018

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The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron

21 January 2018

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Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.

21 January 2018

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Mismatch repair co-opted by hypermutation.

21 January 2018

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Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

21 January 2018

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Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells

21 January 2018

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Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

27 November 2018

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Origin of Antibody Variation

27 November 2018

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Kinetics of oxidized cytosine repair by endonuclease III of Escherichia coli

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/9607916

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutator phenotype in Msh2-deficient murine embryonic fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/9607916

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA replication fidelity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9607916

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.187.11.1745

1 reference

1 reference

1 reference

1 reference