The molecular basis of somatic hypermutation of immunoglobulin genes (Q41049026)

26 September 2017

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title

The molecular basis of somatic hypermutation of immunoglobulin genes (English)

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26 September 2017

Storb U

1

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26 September 2017

publication date

1 April 1996

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Current Opinion in Immunology

26 September 2017

published in

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26 September 2017

volume

8

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26 September 2017

issue

2

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26 September 2017

page(s)

206-214

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Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization

26 September 2017

cites work

1 reference

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7 January 2021

Intraclonal generation of antibody mutants in germinal centres

1 reference

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7 January 2021

Maturation and dispersal of B-cell clones during T cell-dependent antibody responses

1 reference

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7 January 2021

Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Analysis of somatic mutation in five B cell subsets of human tonsil

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Subtle differences in antibody responses and hypermutation of lambda light chains in mice with a disrupted chi constant region

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic hypermutation of VHS107 genes is not associated with gene conversion among family members

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Locus-specific somatic hypermutation in germinal centre T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Antigen-specific development of primary and memory T cells in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Codon bias targets mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic mutation in constant regions of mouse lambda 1 light chains

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic mutation of immunoglobulin light-chain variable-region genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Comparison of somatic mutation frequency among immunoglobulin genes

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Unrearranged immunoglobulin lambda variable region is transcribed in kappa-producing myelomas

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Transcriptional regulation of immunoglobulin V genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

A reporter gene to analyse the hypermutation of immunoglobulin genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loop

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Origin of Antibody Variation

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Clusters of point mutations are found exclusively around rearranged antibody variable genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Templated insertions in the rearranged chicken IgL V gene segment arise by intrachromosomal gene conversion

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Gene conversion: some implications for immunoglobulin genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversi

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Evolution of mouse immunoglobulin lambda genes

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

A detailed model of reverse transcription and tests of crucial aspects

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic mutation and transcriptional deregulation of myc in endemic Burkitt's lymphoma disease: heptamer-nonamer recognition mistakes?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Somatic hypermutation of an immunoglobulin mu heavy chain transgene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Clustered somatic mutations in and around first exon of non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Analysis of somatic mutations in kappa transgenes

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Relationships between DNA repair and transcription

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Transcription-coupled repair and human disease

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

DNA repair comes of age.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

The elongation-termination decision in transcription

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980059-8

7 January 2021

10.1016/S0952-7915(96)80059-8

Identifiers

DOI

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26 September 2017

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