The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium (Q28508627)

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scientific journal article

Language	Label	Description	Also known as
English	The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium	scientific journal article

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scholarly article

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24 January 2017

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium (English)

1 reference

24 January 2017

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Insulin-like growth factor 1

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GOA release 2020-03-11

Insulin-like growth factor I receptor

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GOA release 2020-03-11

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based on heuristic

inferred from title

bioavailability

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based on heuristic

inferred from title

15

object named as

David J. Beech

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24 January 2017

Stephen Wheatcroft

16

object named as

Stephen B Wheatcroft

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24 January 2017

17

object named as

Mark T Kearney

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24 January 2017

object named as

Adil Rajwani

5

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Hema Viswambharan

object named as

Hema Viswambharan

3

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6

object named as

Richard M. Cubbon

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24 January 2017

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2

object named as

Helen Imrie

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24 January 2017

Stacey Galloway

9

object named as

Stacey Galloway

1 reference

24 January 2017

Matthew Benjamin Kahn

11

object named as

Matthew Kahn

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24 January 2017

1

object named as

Afroze Abbas

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24 January 2017

12

object named as

Shouhong Xuan

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24 January 2017

author name string

Piruthivi Sukumar

4

1 reference

24 January 2017

Matthew Gage

7

1 reference

24 January 2017

Jessica Smith

8

1 reference

24 January 2017

Nadira Yuldeshava

10

1 reference

24 January 2017

Peter J. Grant

13

1 reference

24 January 2017

Keith M. Channon

14

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24 January 2017

language of work or name

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publication date

1 August 2011

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24 January 2017

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24 January 2017

60

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24 January 2017

8

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24 January 2017

2169–2178

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24 January 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

30 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

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Obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

19 March 2017

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

19 March 2017

Atherosclerosis — An Inflammatory Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

19 March 2017

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

19 March 2017

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

7 April 2017

Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Cardiovascular actions of insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

IGF-binding protein-2 protects against the development of obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Peripheral arterial disease in patients with diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Structural biology of insulin and IGF1 receptors: implications for drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Application of the nitric oxide donor SNAP to cardiomyocytes in culture provides protection against oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Nitric oxide synthases: which, where, how, and why?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

29 September 2017

The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

2 June 2018

Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

2 June 2018

Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

2 June 2018

Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Vascular insulin-like growth factor-I resistance and diet-induced obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Effect of endothelium-specific insulin resistance on endothelial function in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Rapid regulation of platelet activation in vivo by nitric oxide

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Diabetes as a risk factor for stroke. A population perspective.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142083

27 November 2018

Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial nitric oxide production and insulin sensitivity. A physiological link with implications for pathogenesis of cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB11-0197

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1 reference

24 January 2017

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