Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer (Q36956237)

17 August 2017

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title

Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer (English)

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17 August 2017

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David R Clemmons

1

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PubMed ID

17906644

17 August 2017

language of work or name

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1 October 2007

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Nature Reviews Drug Discovery

17 August 2017

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17 August 2017

6

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17 August 2017

821-833

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17 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd2359

17 August 2017

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cites work

Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle

1 reference

Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels

21 January 2018

1 reference

Reduction in atherosclerotic lesion size in pigs by alphaVbeta3 inhibitors is associated with inhibition of insulin-like growth factor-I-mediated signaling

21 January 2018

1 reference

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

21 January 2018

1 reference

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

21 January 2018

1 reference

Regulation of survival signals from the insulin-like growth factor-I receptor

21 January 2018

1 reference

Differences in the repertoires of basement membrane degrading enzymes in two carcinoma sublines with distinct patterns of site-selective metastasis.

21 January 2018

1 reference

Value of insulin-like growth factor system markers in the assessment of growth hormone status

21 January 2018

1 reference

Normal growth and development in the absence of hepatic insulin-like growth factor I

31 March 2020

1 reference

Induction of insulin-like growth factor I messenger ribonucleic acid during regeneration of rat skeletal muscle

31 March 2020

1 reference

Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation

31 March 2020

1 reference

Recovery of articular cartilage metabolism following thermal stress is facilitated by IGF-1 and JNK inhibitor

31 March 2020

1 reference

IGF-I and microglia/macrophage proliferation in the ischemic mouse brain.

31 March 2020

1 reference

Growth factor-specific regulation of insulin receptor substrate-1 expression in MCF-7 breast carcinoma cells: effects on the insulin-like growth factor signaling pathway

31 March 2020

1 reference

The insulin-like growth factor system in vascular smooth muscle: interaction with insulin and growth factors

31 March 2020

1 reference

Targeting insulin-like growth factor pathways.

31 March 2020

1 reference

Insulin-like growth factors and their receptors in growth

31 March 2020

1 reference

Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression

31 March 2020

1 reference

Regulation of insulin-like growth factor messenger ribonucleic acid in rat growth plate by growth hormone

31 March 2020

1 reference

A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans

31 March 2020

1 reference

Insulin-like growth factors in the fed and fasted states.

31 March 2020

1 reference

6 Factors controlling blood concentration of somatomedin C

31 March 2020

1 reference

Estrogen regulation of growth hormone action.

31 March 2020

1 reference

Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations

31 March 2020

1 reference

Role of the time factor in signaling specificity: application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases

31 March 2020

1 reference

The IGF-I signaling pathway

31 March 2020

1 reference

Free insulin-like growth factors -- measurements and relationships to growth hormone secretion and glucose homeostasis

31 March 2020

1 reference

Circulating levels and molecular distribution of the acid-labile (alpha) subunit of the high molecular weight insulin-like growth factor-binding protein complex.

31 March 2020

1 reference

Radioimmunoassay of a 26,000-dalton plasma insulin-like growth factor-binding protein: control by nutritional variables.

31 March 2020

1 reference

Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells

31 March 2020

1 reference

Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting

31 March 2020

1 reference

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

31 March 2020

1 reference

Insulin-like growth factor-I treatment of growth disorders, diabetes mellitus and insulin resistance

31 March 2020

1 reference

Molecular mechanisms of IGF-I deficiency

31 March 2020

1 reference

Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance

31 March 2020

1 reference

Anabolic effects of insulin-like growth factor in combination with insulin-like growth factor binding protein-3 in severely burned adults

31 March 2020

1 reference

Metabolic and clinical response to recombinant human insulin-like growth factor I in myotonic dystrophy--a clinical research center study

31 March 2020

1 reference

A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group

31 March 2020

1 reference

Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group

31 March 2020

1 reference

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

31 March 2020

1 reference

Trial of insulinlike growth factor I therapy for patients with extreme insulin resistance syndromes.

31 March 2020

1 reference

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

31 March 2020

1 reference

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus

31 March 2020

1 reference

Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes

31 March 2020

1 reference

Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group

31 March 2020

1 reference

Improvement of HbA1c without increased hypoglycemia in adolescents and young adults with type 1 diabetes mellitus treated with recombinant human insulin-like growth factor-I and insulin. rhIGF-I in IDDM Study Group

31 March 2020

1 reference

Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes

31 March 2020

1 reference

Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose

31 March 2020

1 reference

Growth promoting and metabolic activity of the human insulin analogue [GlyA21,ArgB31,ArgB32]insulin (HOE 901) in muscle cells

31 March 2020

1 reference

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

31 March 2020

1 reference

Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures

31 March 2020

1 reference

Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor

31 March 2020

1 reference

Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture

31 March 2020

1 reference

Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins

31 March 2020

1 reference

Identification of a nonpeptide ligand that releases bioactive insulin-like growth factor-I from its binding protein complex

31 March 2020

1 reference

Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds

31 March 2020

1 reference

Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study

31 March 2020

1 reference

A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction

31 March 2020

1 reference

Effects of hypophysectomy on vascular insulin-like growth factor-I gene expression after balloon denudation in rats

31 March 2020

1 reference

Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury

31 March 2020

1 reference

Angiotensin II activation of insulin-like growth factor 1 receptor transcription is mediated by a tyrosine kinase-dependent redox-sensitive mechanism

31 March 2020

1 reference

Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins

31 March 2020

1 reference

Angiotensin II stimulates gene expression of cardiac insulin-like growth factor I and its receptor through effects on blood pressure and food intake

31 March 2020

1 reference

Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia.

31 March 2020

1 reference

Localization of insulin-like growth factor I and inhibition of coronary smooth muscle cell growth by somatostatin analogues in human coronary smooth muscle cells. A potential treatment for restenosis?

31 March 2020

1 reference

Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor

31 March 2020

1 reference

Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells

31 March 2020

1 reference

The IGF system and breast cancer

31 March 2020

1 reference

Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor

31 March 2020

1 reference

Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor

31 March 2020

1 reference

The insulin-like growth factor axis in cell cycle progression

31 March 2020

1 reference

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

31 March 2020

1 reference

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

31 March 2020

1 reference

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

31 March 2020

1 reference

Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis.

31 March 2020

1 reference

IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai

31 March 2020

1 reference

Endometrial cancer and the IGF system: a case-control study in Greece.

31 March 2020

1 reference

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk

31 March 2020

1 reference

Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor

31 March 2020

1 reference

Expression of insulin-like growth factor-1 receptor in human colorectal cancer

31 March 2020

1 reference

Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival.

31 March 2020

1 reference

Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.

31 March 2020

1 reference

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

31 March 2020

1 reference

Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.

31 March 2020

1 reference

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor

31 March 2020

1 reference

Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling

31 March 2020

1 reference

Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals

31 March 2020

1 reference

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

31 March 2020

1 reference

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

31 March 2020

1 reference

Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism

31 March 2020

1 reference

Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.

31 March 2020

1 reference

Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects

31 March 2020

1 reference

Increased expression of insulin-like growth factor i is associated with Ara-C resistance in leukemia

31 March 2020

1 reference

Overexpression of the insulin-like growth factor I receptor in human colon carcinomas

31 March 2020

1 reference

Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas

31 March 2020

1 reference

Discordant expression of insulin-like growth factors and their receptor messenger ribonucleic acids in endometrial carcinomas relative to normal endometrium

31 March 2020

1 reference

Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two beta subunits are derived from differences in glycosylation.

31 March 2020

1 reference

IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding.

31 March 2020

1 reference

Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells

31 March 2020

1 reference

ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3

31 March 2020

1 reference

Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability

31 March 2020

1 reference

Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3.

31 March 2020

1 reference

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

31 March 2020

1 reference

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

31 March 2020

1 reference

A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts

31 March 2020

1 reference

A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.

31 March 2020

1 reference

Insulin-like growth factor-I receptor signaling blockade combined with radiation

31 March 2020

1 reference

Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo.

31 March 2020

1 reference

In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors

31 March 2020

1 reference

The role of the IGF system in cancer growth and metastasis: overview and recent insights

31 March 2020

1 reference

Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.

31 March 2020

1 reference

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

31 March 2020

1 reference

The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy

31 March 2020

1 reference

Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor.

31 March 2020

1 reference

Insulin-like growth factor receptor I targeting in epithelial ovarian cancer

31 March 2020

1 reference

The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells

31 March 2020

1 reference

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

31 March 2020

1 reference

Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor

31 March 2020

1 reference

Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas.

31 March 2020

1 reference

mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

31 March 2020

1 reference

Crosstalk between IGF signaling and steroid hormone receptors in breast cancer

31 March 2020

1 reference

Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor

31 March 2020

1 reference

Smoking induces glomerulosclerosis in aging estrogen-deficient mice through cross-talk between TGF-beta1 and IGF-I signaling pathways.

31 March 2020

1 reference

31 March 2020

1 reference

Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.

31 March 2020

1 reference

Therapeutic potential of chimeric anti-(ganglioside GD3) antibody KM871: antitumor activity in xenograft model of melanoma and effector function analysis

31 March 2020

1 reference

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody

31 March 2020

1 reference

Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

31 March 2020

1 reference

Blockade of paracrine supply of insulin-like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers

31 March 2020

1 reference

Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer.

31 March 2020

1 reference

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

31 March 2020

1 reference

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity

31 March 2020

1 reference

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

31 March 2020

1 reference

Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

31 March 2020

1 reference

Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo.

31 March 2020

1 reference

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

31 March 2020

1 reference

Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma

31 March 2020

1 reference

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth

31 March 2020

1 reference

Stabile D-peptide analog of insulin-like growth factor-1 inhibits smooth muscle cell proliferation after carotid ballooning injury in the rat.

31 March 2020

1 reference

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7 January 2021

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Identifiers

DOI

10.1038/NRD2359

1 reference

PubMed ID

17906644

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17906644