Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis (Q28511495)

GOA release 2020-03-11

1 reference

Xiang Xue

1

1 reference

25 January 2017

Matthew Taylor

2

1 reference

25 January 2017

Erik Anderson

3

1 reference

25 January 2017

Cathy Hao

4

1 reference

25 January 2017

Aijuan Qu

5

1 reference

25 January 2017

Joel K. Greenson

6

1 reference

25 January 2017

Ellen M. Zimmermann

7

1 reference

25 January 2017

Frank J. Gonzalez

8

1 reference

25 January 2017

Yatrik M. Shah

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

9

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25 January 2017

language of work or name

English

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publication date

1 May 2012

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25 January 2017

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25 January 2017

72

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25 January 2017

2285–2293

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25 January 2017

9

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25 January 2017

1 reference

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19 March 2017

Cancer statistics, 2008

1 reference

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

19 March 2017

1 reference

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The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1

19 March 2017

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

19 March 2017

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

19 March 2017

1 reference

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19 March 2017

1 reference

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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

19 March 2017

1 reference

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

19 March 2017

2 references

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19 March 2017

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Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

29 September 2017

1 reference

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

19 March 2017

1 reference

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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

19 March 2017

1 reference

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

19 March 2017

1 reference

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General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

19 March 2017

1 reference

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Disruption of epithelial cell-matrix interactions induces apoptosis

19 March 2017

1 reference

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

19 March 2017

1 reference

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

19 March 2017

1 reference

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The impact of O2 availability on human cancer

7 April 2017

1 reference

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Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

MCM proteins are negative regulators of hypoxia-inducible factor 1.

29 September 2017

1 reference

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Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

HIF-1 and HIF-2 transcription factors--similar but not identical

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Suppression of cyclin D1 by hypoxia-inducible factor-1 via direct mechanism inhibits the proliferation and 5-fluorouracil-induced apoptosis of A549 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis

29 September 2017

1 reference

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Integrative analysis of the cancer transcriptome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Iron and colorectal cancer risk: human studies.

29 September 2017

1 reference

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

29 September 2017

1 reference

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Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.

29 September 2017

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Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Body iron stores and risk of colonic neoplasia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Dietary iron enhances the tumor rate in dimethylhydrazine-induced colon carcinogenesis in mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Influence of dietary iron overload on cell proliferation and intestinal tumorigenesis in mice.

2 June 2018

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Role of cell shape in growth control

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342485

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

27 November 2018

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Transcriptome profile of human colorectal adenomas.

27 November 2018

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Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat.

27 November 2018

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Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis

27 November 2018

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Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice

27 November 2018

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Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron

27 November 2018

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PubMed

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12 December 2020

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The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis

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PubMed

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inferred from PubMed ID database lookup

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Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias

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PubMed

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