The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer (Q37299263)

19 August 2017

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title

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer (English)

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19 August 2017

1

William G Kaelin

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19 August 2017

language of work or name

English

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publication date

16 October 2008

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19 August 2017

published in

Nature Reviews Cancer

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19 August 2017

volume

8

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19 August 2017

issue

11

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19 August 2017

page(s)

865-873

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

19 August 2017

cites work

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

31 March 2020

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

31 March 2020

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

31 March 2020

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

31 March 2020

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

31 March 2020

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

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A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

31 March 2020

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

31 March 2020

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Von Hippel-Lindau disease.

31 March 2020

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Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

31 March 2020

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Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

31 March 2020

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

31 March 2020

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

31 March 2020

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The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

31 March 2020

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

31 March 2020

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

31 March 2020

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

31 March 2020

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

31 March 2020

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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

31 March 2020

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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

31 March 2020

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Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

31 March 2020

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Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors

31 March 2020

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Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

31 March 2020

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

31 March 2020

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PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis

31 March 2020

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

31 March 2020

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

31 March 2020

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

31 March 2020

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The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha

31 March 2020

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Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

31 March 2020

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VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

31 March 2020

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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

31 March 2020

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Tumour suppression by the human von Hippel-Lindau gene product

31 March 2020

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

31 March 2020

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

31 March 2020

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The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

31 March 2020

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

31 March 2020

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

31 March 2020

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HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation

31 March 2020

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Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

31 March 2020

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

31 March 2020

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

31 March 2020

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Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

31 March 2020

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

31 March 2020

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Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

31 March 2020

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Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

31 March 2020

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

31 March 2020

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Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

31 March 2020

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Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

31 March 2020

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Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein

31 March 2020

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Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment

31 March 2020

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The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo

31 March 2020

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Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

31 March 2020

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Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein

31 March 2020

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RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

31 March 2020

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

31 March 2020

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Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha

31 March 2020

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HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

31 March 2020

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

31 March 2020

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

31 March 2020

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

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Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells

31 March 2020

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Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma

31 March 2020

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RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

31 March 2020

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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

31 March 2020

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Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

31 March 2020

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Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer

31 March 2020

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Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

31 March 2020

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Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

31 March 2020

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VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

31 March 2020

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The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

31 March 2020

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

31 March 2020

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Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells

31 March 2020

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Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension

31 March 2020

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Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma.

31 March 2020

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The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells

31 March 2020

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

31 March 2020

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

31 March 2020

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

31 March 2020

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

31 March 2020

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The hypoxic response of tumors is dependent on their microenvironment.

31 March 2020

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

31 March 2020

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Targeting HIF-1 for cancer therapy

31 March 2020

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Role of primary cilia in the pathogenesis of polycystic kidney disease

31 March 2020

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The primary cilium as the cell's antenna: signaling at a sensory organelle

31 March 2020

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Primary cilium formation requires von hippel-lindau gene function in renal-derived cells

31 March 2020

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Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein

31 March 2020

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pVHL and GSK3beta are components of a primary cilium-maintenance signalling network

31 March 2020

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The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

31 March 2020

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Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor

31 March 2020

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Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

31 March 2020

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The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

31 March 2020

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pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

31 March 2020

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Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.

31 March 2020

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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

31 March 2020

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Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

31 March 2020

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Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2

31 March 2020

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

31 March 2020

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pVHL function is essential for endothelial extracellular matrix deposition.

31 March 2020

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Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis

31 March 2020

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pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

31 March 2020

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NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL

31 March 2020

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Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region

31 March 2020

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Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma

31 March 2020

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Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

31 March 2020

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

31 March 2020

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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

31 March 2020

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Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation

31 March 2020

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The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

31 March 2020

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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

31 March 2020

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KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death

31 March 2020

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pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2

31 March 2020

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p53 stabilization and transactivation by a von Hippel-Lindau protein

31 March 2020

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The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

31 March 2020

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An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association

31 March 2020

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von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter

31 March 2020

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

31 March 2020

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Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma

31 March 2020

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The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

31 March 2020

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von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

31 March 2020

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The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress

31 March 2020

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Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

31 March 2020

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Sorafenib in advanced clear-cell renal-cell carcinoma

31 March 2020

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Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study

31 March 2020

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Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial

31 March 2020

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

31 March 2020

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A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

31 March 2020

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

31 March 2020

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

31 March 2020

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Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression

31 March 2020

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Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2502

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Dimensions Publication ID

19 August 2017

1005917553

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