Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells (Q28511967)

25 January 2017

title

Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells (English)

1 reference

Related RAS viral (r-ras) oncogene

25 January 2017

main subject

1 reference

GOA release 2020-03-11

Neurofibromin 1

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Related RAS viral (r-ras) oncogene 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

0 references

1 reference

Yuan Huang

1

1 reference

25 January 2017

Fatima Rangwala

2

1 reference

25 January 2017

Patricia C. Fulkerson

3

1 reference

25 January 2017

Bo Ling

4

1 reference

25 January 2017

Erin Reed

5

1 reference

25 January 2017

Adrienne D. Cox

6

1 reference

25 January 2017

John Kamholz

7

1 reference

25 January 2017

Nancy Ratner

8

1 reference

25 January 2017

language of work or name

English

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publication date

15 January 2004

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25 January 2017

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25 January 2017

volume

23

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25 January 2017

issue

2

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25 January 2017

page(s)

368–378

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The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes

25 January 2017

cites work

1 reference

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19 March 2017

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Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3

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Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells

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19 March 2017

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19 March 2017

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Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

19 March 2017

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Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation

19 March 2017

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The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

19 March 2017

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Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

19 March 2017

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Activation of the Ral and phosphatidylinositol 3' kinase signaling pathways by the ras-related protein TC21.

29 September 2017

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Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains

29 September 2017

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29 September 2017

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Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells

29 September 2017

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TC21 and Ras share indistinguishable transforming and differentiating activities

29 September 2017

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Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.

29 September 2017

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29 September 2017

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29 September 2017

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Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

29 September 2017

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Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers

29 September 2017

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Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

29 September 2017

1 reference

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R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells

29 September 2017

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Construction and applications of a highly transmissible murine retrovirus shuttle vector

29 September 2017

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Angiogenic and invasive properties of neurofibroma Schwann cells

29 September 2017

1 reference

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Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization

29 September 2017

1 reference

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Analyses of TC21/R-Ras2 signaling and biological activity

2 June 2018

1 reference

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Activation of R-Ras by Ras-guanine nucleotide-releasing factor

2 June 2018

1 reference

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R-Ras is regulated by activators and effectors distinct from those that control Ras function

2 June 2018

1 reference

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R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation

2 June 2018

1 reference

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Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype

2 June 2018

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Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854497

Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression

2 June 2018

1 reference

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Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal

2 June 2018

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The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

2 June 2018

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Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

2 June 2018

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p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

2 June 2018

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Crossref

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207075

Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas

21 January 2018

1 reference

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Measurement of GTP-bound Ras-like GTPases by activation-specific probes

27 November 2018

1 reference

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Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854497

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

27 November 2018

1 reference

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Integrin activation by R-ras.

27 November 2018

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Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function

27 November 2018

1 reference

12 December 2020

Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes

1 reference

12 December 2020

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

12 December 2020

Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma

1 reference

12 December 2020

Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1 reference

12 December 2020

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1 reference

12 December 2020

Dimensions Publication ID

Identifiers

DOI

10.1038/SJ.ONC.1207075

0 references

1045829746

0 references

PMC publication ID

2854497

0 references

1 reference