Neurofibromin 1 (Q21987763)

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mammalian protein found in Mus musculus
  • neurofibromin
  • neurofibromatosis-related protein NF-1
  • Nf1
  • neurofibromatosis 1
edit
Language Label Description Also known as
English
Neurofibromin 1
mammalian protein found in Mus musculus
  • neurofibromin
  • neurofibromatosis-related protein NF-1
  • Nf1
  • neurofibromatosis 1

Statements

molecular function
GTPase activator activity
determination method
IGI
IEA
IMP
ISO
7 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
ISO
retrieved
8 April 2019
stated in
Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q04690
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IEA
cell component
biological process
negative regulation of Ras protein signal transduction
determination method
IGI
IMP
7 references
retrieved
8 April 2019
stated in
Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
Ras protein signal transduction
determination method
IGI
IMP
7 references
retrieved
8 April 2019
stated in
The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1 has an essential role in endothelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
negative regulation of cell population proliferation
determination method
IGI
IMP
18 references
retrieved
8 April 2019
stated in
Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Mouse models of tumor development in neurofibromatosis type 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Mouse tumor model for neurofibromatosis type 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
negative regulation of cell migration
determination method
IGI
IEA
IMP
ISO
6 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
ISO
retrieved
8 April 2019
stated in
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IMP
retrieved
8 April 2019
stated in
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
determination method
IEA

Identifiers

 
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