Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase (Q28588037)

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English	Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase	scientific journal article

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scholarly article

1 reference

31 January 2017

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase (English)

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31 January 2017

Neurofibromin 1

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GOA release 2020-03-11

mouse Schwann cell

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

H. A. Kim

1

1 reference

31 January 2017

B. Ling

2

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31 January 2017

N. Ratner

3

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31 January 2017

language of work or name

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publication date

1 February 1997

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31 January 2017

Molecular and Cellular Biology

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31 January 2017

17

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31 January 2017

2

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31 January 2017

862–872

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31 January 2017

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

17 March 2017

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

17 March 2017

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

17 March 2017

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

17 March 2017

Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

17 March 2017

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

17 March 2017

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

17 March 2017

The neurofibromatosis type 1 gene encodes a protein related to GAP

1 reference

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17 March 2017

Neuropeptides in cutaneous neurofibromas of von Recklinghausen's disease

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17 March 2017

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

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17 March 2017

A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples

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7 April 2017

Neurofibromin-deficient fibroblasts fail to form perineurium in vitro

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29 September 2017

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

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29 September 2017

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

29 September 2017

Angiogenesis inhibition: a review

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

29 September 2017

Growth factors and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

29 September 2017

Forskolin: a unique diterpene activator of cyclic AMP-generating systems

1 reference

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29 September 2017

Transfection with plasmid pSV2gptEJ induces chromosome rearrangements in CHEF cells

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29 September 2017

Specific asparagine-linked oligosaccharides are not required for certain neuron-neuron and neuron-Schwann cell interactions

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29 September 2017

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation

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29 September 2017

Biochemical mechanisms of tumor invasion and metastases

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29 September 2017

Molecular genetic analysis of tumors in von Recklinghausen neurofibromatosis: loss of heterozygosity for chromosome 17.

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29 September 2017

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis

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29 September 2017

Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis

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29 September 2017

Angiogenic and invasive properties of neurofibroma Schwann cells

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29 September 2017

Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels

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29 September 2017

Study on the ultrastructure and acetylcholinesterase activity in von Recklinghausen's neurofibromatosis

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29 September 2017

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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3 June 2018

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

3 June 2018

Regulation of basic fibroblast growth factor mRNA expression in rat C6 glioma cells.

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3 June 2018

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

3 June 2018

Suppression of Ras transformation by serum response factor.

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3 June 2018

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation

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3 June 2018

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

1 reference

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3 June 2018

Calcitonin gene-related peptide promotes Schwann cell proliferation

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3 June 2018

Inhibition by cAMP of Ras-dependent activation of Raf.

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3 June 2018

Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype

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3 June 2018

Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes

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3 June 2018

Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression

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3 June 2018

Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

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3 June 2018

Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype

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3 June 2018

Purification of 18- and 22-kDa forms of basic fibroblast growth factor from rat cells transformed by the ras oncogene.

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3 June 2018

Cellular differentiation and expression of matrix genes in type 1 neurofibromatosis

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3 June 2018

Secreted proteases. Regulation of their activity and their possible role in metastasis

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3 June 2018

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231813

3 June 2018

Genetic instability and the acquisition of metastatic ability by rat mammary cancer cells following v-H-ras oncogene transfection

1 reference

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3 June 2018

Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues

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3 June 2018

Neurofibromatosis: past, present, and future

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3 June 2018

Purification and characterization of biologically active scatter factor from ras-transformed NIH 3T3 conditioned medium

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3 June 2018

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3 June 2018

The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition

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3 June 2018

Interaction between cAMP elevation, identified growth factors, and serum components in regulating Schwann cell growth

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3 June 2018

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

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3 June 2018

Schwann cells and cells in the oligodendrocyte lineage proliferate in response to a 50,000 dalton membrane-associated mitogen present in developing brain

1 reference

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3 June 2018

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1 reference

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3 June 2018

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3 June 2018

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

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27 November 2018

TP53 mutations are frequent in malignant NF1 tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

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Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of microsatellites in neurofibromas of von Recklinghausen's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

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inferred from PubMed ID database lookup

Neurofibromas in von recklinghausen's disease. Ultrastructural study and nosologic relation to neurinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell culture studies on neurofibromatosis (von Recklinghausen). Characterization of cells growing from neurofibromas

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-expression of alpha-CGRP and beta-CGRP mRNAs in the rat dorsal root ganglion cells

1 reference

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12 December 2020

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Peripheral nerve section induces increased levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity in axotomized motoneurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

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inferred from PubMed ID database lookup

Mitogen accumulation in von Recklinghausen neurofibromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

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Identification of NF1 mutations in both alleles of a dermal neurofibroma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

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inferred from PubMed ID database lookup

Malignant peripheral nerve sheath tumors in childhood

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

based on heuristic

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Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

based on heuristic

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Degradation of endothelial cell matrix collagen is correlated with induction of stromelysin by an activated ras oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/9001241

12 December 2020

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Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1 reference

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10.1128/MCB.17.2.862

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31 January 2017

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