Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species (Q28511985)

GOA release 2020-03-11

16

David Winlaw

1 reference

25 January 2017

Georg Vogler

5

0 references

Benoit G. Bruneau

Benoit G. Bruneau

23

0 references

Sally L. Dunwoodie

Sally Dunwoodie

15

0 references

Jeffrey A Towbin

19

Jeffrey A. Towbin

1 reference

25 January 2017

Christopher Semsarian

14

Christopher Semsarian

1 reference

25 January 2017

0 references

Li Qian

1

1 reference

25 January 2017

Joshua D. Wythe

2

1 reference

25 January 2017

Jiandong Liu

3

1 reference

25 January 2017

Jerome Cartry

4

1 reference

25 January 2017

Bhagyalaxmi Mohapatra

6

1 reference

25 January 2017

Robyn T. Otway

7

1 reference

25 January 2017

Yu Huang

8

1 reference

25 January 2017

Isabelle N. King

9

1 reference

25 January 2017

Marjorie Maillet

10

1 reference

25 January 2017

Yi Zheng

11

1 reference

25 January 2017

Timothy Crawley

12

1 reference

25 January 2017

Ouarda Taghli-Lamallem

13

1 reference

25 January 2017

Richard P. Harvey

17

1 reference

25 January 2017

Diane Fatkin

18

1 reference

25 January 2017

Jeffery D. Molkentin

20

1 reference

25 January 2017

Deepak Srivastava

21

1 reference

25 January 2017

Karen Ocorr

22

1 reference

25 January 2017

Rolf Bodmer

Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K

24

1 reference

25 January 2017

language of work or name

English

0 references

publication date

27 June 2011

1 reference

25 January 2017

Journal of Cell Biology

1 reference

25 January 2017

193

1 reference

25 January 2017

7

1 reference

25 January 2017

1181–1196

1 reference

25 January 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Drosophila, an emerging model for cardiac disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Congenital heart disease caused by mutations in the transcription factor NKX2-5

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Mammalian Rho GTPases: new insights into their functions from in vivo studies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

MicroRNA-133 controls cardiac hypertrophy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Gene regulatory networks in the evolution and development of the heart

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Semi-automated Optical Heartbeat Analysis of small hearts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Cdc42 is an antihypertrophic molecular switch in the mouse heart

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Partial loss of GATA factor Pannier impairs adult heart function in Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Making or breaking the heart: from lineage determination to morphogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

The Rac and Rho hall of fame: a decade of hypertrophic signaling hits

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Drosophila, the golden bug, emerges as a tool for human genetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Developmental paradigms in heart disease: insights from tinman

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Control of cardiac development by an evolutionarily conserved transcriptional network

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

From sequence to phenotype: reverse genetics in Drosophila melanogaster

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

The art and design of genetic screens: Drosophila melanogaster

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Small guanine nucleotide-binding proteins and myocardial hypertrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Characterization of components of Z-bands in the fibrillar flight muscle of Drosophila melanogaster

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Visualizing the beating heart in Drosophila

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Genetic and pharmacological identification of ion channels central to the Drosophila cardiac pacemaker

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation.

2 June 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Heart development in Drosophila and its relationship to vertebrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesoderm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Slit and Robo control cardiac cell polarity and morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Insulin regulation of heart function in aging fruit flies

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201006114

Screening assays for heart function mutants in Drosophila.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3216339

GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21690310

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201006114

1 reference

1311376

1311376

1 reference

1 reference

1 reference