Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane (Q28568133)

https://api.crossref.org/works/10.1074/JBC.M304009200

31 December 2023

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31 December 2023

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1

Stephen H. Pasternak

1 reference

Europe PubMed Central

PubMed ID

12736250

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12736250

31 December 2023

author name string

Richard D. Bagshaw

2

1 reference

31 January 2017

Marianne Guiral

3

1 reference

31 January 2017

Sunqu Zhang

4

1 reference

31 January 2017

Cameron A. Ackerley

5

1 reference

31 January 2017

Brian J. Pak

6

1 reference

31 January 2017

John W. Callahan

7

1 reference

31 January 2017

Don J. Mahuran

8

1 reference

31 January 2017

language of work or name

English

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publication date

18 July 2003

1 reference

31 January 2017

7 May 2003

1 reference

Europe PubMed Central

PubMed ID

12736250

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12736250

full work available at URL

31 December 2023

http://www.jbc.org/article/S0021925820846237/pdf

file format

Portable Document Format

online access status

open access

1 reference

Europe PubMed Central

PubMed ID

12736250

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12736250

https://api.elsevier.com/content/article/PII:S0021925820846237?httpAccept=text/xml

31 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M304009200

https://api.elsevier.com/content/article/PII:S0021925820846237?httpAccept=text/plain

31 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M304009200

https://syndication.highwire.org/content/doi/10.1074/jbc.M304009200

31 December 2023

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https://api.crossref.org/works/10.1074/JBC.M304009200

Journal of Biological Chemistry

31 December 2023

published in

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31 January 2017

278

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29

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26687–26694

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31 January 2017

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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Presenilins: molecular switches between proteolysis and signal transduction

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

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Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

21 January 2018

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

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Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

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Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

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Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

21 January 2018

1 reference

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Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

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Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.

21 January 2018

1 reference

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Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

21 January 2018

1 reference

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

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Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage

21 January 2018

1 reference

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Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

21 January 2018

1 reference

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

1 reference

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Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

21 January 2018

1 reference

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Cell surface expression of the Alzheimer disease-related presenilin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M304009200

Nicastrin is a resident lysosomal membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

The large-scale separation of peroxisomes, mitochondria, and lysosomes from the livers of rats injected with triton WR-1339. Improved isolation procedures, automated analysis, biochemical and morphological properties of fractions

21 January 2018

1 reference

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Intracellular hormone receptors: evidence for insulin and lactogen receptors in a unique vesicle sedimenting in lysosome fractions of rat liver

21 January 2018

1 reference

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Characterization of the membrane proteins of rat liver lysosomes. Composition, enzyme activities and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Proteomics of rat liver Golgi complex: minor proteins are identified through sequential fractionation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Intracellular trafficking of lysosomal membrane proteins.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M304009200

Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Role of endoplasmic reticulum, endosomal-lysosomal compartments, and microtubules in amyloid precursor protein metabolism of human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

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Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

In vitro processing of amyloid precursor protein by cathepsin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid

21 January 2018

1 reference

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Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

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Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide

21 January 2018

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Proteases and proteolysis in the lysosome

21 January 2018

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Regulated secretion of conventional lysosomes

21 January 2018

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Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304009200

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

21 January 2018

1 reference

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The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

21 January 2018

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Cellular membrane composition defines A beta-lipid interactions

21 January 2018

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Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption

21 January 2018

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Organelle-specific initiation of cell death pathways

21 January 2018

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Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

21 January 2018

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Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

21 January 2018

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Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

21 January 2018

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Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

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Cerebellar diffuse amyloid plaques are derived from dendritic Abeta42 accumulations in Purkinje cells

21 January 2018

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Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

21 January 2018

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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

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Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

21 January 2018

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Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

31 December 2023

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The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

31 December 2023

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Processing of the beta-amyloid precursor protein in ex vivo human brain cells

31 December 2023

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Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

31 December 2023

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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

31 December 2023

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Light and electron microscopic localization of presenilin-1 in primate brain.

31 December 2023

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Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

31 December 2023

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Subcellular distribution and turnover of presenilins in transfected cells

31 December 2023

39

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Discrimination of the isozymes of human placental hexosaminidase by kinetic parameter estimation

31 December 2023

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Influence of the injection of "Triton WR-1339" on lysosomes of a rat transplantable hepatoma

31 December 2023

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Phagocytosis by rat liver: relationships between phagosomes and lysosomes

31 December 2023

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Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

31 December 2023

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Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

31 December 2023

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Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

31 December 2023

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Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.

31 December 2023

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Identifiers

1 reference

Consolidated OpenCitations Corpus – April 2017

2835306

2835306

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference